Elevated adenosine deaminase activity in overweightand obese Indian subjects.
Summary of "Elevated adenosine deaminase activity in overweightand obese Indian subjects."
Objective: To determine adenosine deaminase activity in overweight and obese Indian subjects. Methods: This study comprised of 100 subjects. The body mass index (BMI) of subjects was calculated and adenosine deaminase activity was determined in their fasting blood sample. The study was divided into three groups depending upon
Control (n = 40, BMI < 25 kg/m(2)), Overweight (n = 30, BMI 25-29.9 kg/m(2)) and Obese (n = 30, BMI ≥ 30 kg/m(2)). Results: The serum adenosine deaminase activity was significantly increased in overweight and obese subjects and as well as in combined overweight and obese group as compared to control (P < 0.0001). Conclusion: Adenosine, an endogenous anti-inflammatory metabolite, is increased in response to inflammation produced by adipose tissue in obesity. However, adenosine deaminase acts on adenosine to convert it into inosine, thereby increasing adenosine deaminase activity in overweight and obese Indian subjects.
Department of Biochemistry, People's College of Medical Sciences and Research Center, Bhopal , Madhya Pradesh , India.
This article was published in the following journal.
Name: Archives of physiology and biochemistry
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21859364
- DOI: http://dx.doi.org/10.3109/13813455.2011.603341
Medical and Biotech [MESH] Definitions
Adenosine Deaminase Inhibitors
Drugs that inhibit ADENOSINE DEAMINASE activity.
A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
An enzyme that catalyzes the hydrolysis of adenosine to inosine with the elimination of ammonia. Since there are wide tissue and species variations in the enzyme, it has been used as a tool in the study of human and animal genetics and in medical diagnosis. EC 22.214.171.124.
A stable adenosine A1 and A2 receptor agonist. Experimentally, it inhibits cAMP and cGMP phosphodiesterase activity.
A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
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