Advertisement

Topics

Reactivity of Nickel(II) and Copper(II) Complexes of a β-Aminohydrazone Ligand with Pyridine-2-aldehyde: Macrocyclization vs Unprecedented Pyrazole Ring Synthesis via C-C Bond-Forming Reaction.

Summary of "Reactivity of Nickel(II) and Copper(II) Complexes of a β-Aminohydrazone Ligand with Pyridine-2-aldehyde: Macrocyclization vs Unprecedented Pyrazole Ring Synthesis via C-C Bond-Forming Reaction."

The synthesis and characterization of a mononuclear nickel(II) complex [Ni(L(2))](ClO(4))(2) (1) and an analogous mononuclear copper(II) complex [Cu(L(2))](ClO(4))(2) (2) of a 15-membered azamacrocycle (L(2) = 3-(2-pyridyl)-6,8,8,13,13,15-hexamethyl-1,2,4,5,9,12-hexaazacyclopentadeca-5,15-diene) are reported. The macrocyclic ligand is formed during the reaction of 4,4,9,9-tetramethyl-5,8-diazadodecane-2,11-dione dihydrazone (L(1)) with pyridine-2-aldehyde (PyCHO) templated by metal ions. The X-ray crystal structure of 1 exhibits a distorted square-pyramidal coordination geometry, where the metal ion sits in the macrocyclic cavity and the pendant pyridine group of L(2) occupies the axial position. While 1 is stable in the presence of an excess of PyCHO, 2 reacts further with copper(II) salt and PyCHO to form a mononuclear copper(I) complex, [Cu(H(2)L(3))](ClO(4))(3) (3). The structure of the complex cation of 3 reveals a distorted tetrahedral coordination geometry at the copper center with a pseudo 2-fold screw axis. A two-dimensional (2D) polymeric copper(II) complex, {[Cu(2)(L(4))(2)](ClO(4))(2)}(n) (4) is obtained by reacting complex 2 (or [Ni(L(1))](ClO(4))(2)) with copper(II) perchlorate and pyridine-2-aldehyde in a methanol-water solvent mixture. Complex 4 is also obtained by treating 3 with copper(II) perchlorate and pyridine-2-aldehyde in the presence of a base. The X-ray structural analysis of 4 confirms the formation of a pyrazolate bridged dimeric copper(II) complex. The extended structure in the solid state of 4 revealed the formation of a 2D coordination polymer with the dimeric core as the repeating unit. The ligand (HL(4)) in 4 is a 3,4,5-trisubstituted pyrazole ring formed in situ via C-C bond formation and represents an unprecedented transformation reaction.

Affiliation

Department of Inorganic Chemistry, Indian Association for the Cultivation of Science , 2A & 2B Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, India.

Journal Details

This article was published in the following journal.

Name: Inorganic chemistry
ISSN: 1520-510X
Pages: 8012-9

Links

DeepDyve research library

PubMed Articles [4654 Associated PubMed Articles listed on BioPortfolio]

Copper(I) Complexes of Pyridine-Bridged Phosphaalkene-Oxazoline Pincer Ligands.

The synthesis of enantiomerically pure pyridine-bridged phosphaalkene-oxazolines ArP═C(Ph)(2,6-C5H3NOx) (1, Ar = Mes/Mes*, Ox = CNOCH(i-Pr)CH2/CNOCH(CH2Ph)CH2) is reported. This new ligand forms a ...

Reaction of a polydentate cysteine-based ligand and its nickel(ii) complex with electrophilic and nucleophilic methyl-transfer reagents - from S-methylation to acetyl coenzyme A synthase reactivity.

The l-cysteine derived N2S2 ligand precursor H2L and its nickel(ii) complex L2Ni2 were investigated with respect to their behaviour in contact with electrophilic and nucleophilic methylation reagents ...

Controlling the Reactivity of the Boronyl Group in Platinum Complexes toward Cyclodimerization: A Theoretical Survey.

A theoretical study of the cyclodimerization of (Cy3P)2Pt(BO)Br (1Br) and [(Cy3P)2Pt(BO)](+) (1) (Cy = cyclohexyl) suggests that the reactivity of the BO ligand is primarily controlled by M←BO σ do...

Systematic Introduction of Aromatic Rings to Diphosphine Ligands for Emission Color Tuning of Dinuclear Copper(I) Iodide Complexes.

We have newly synthesized two solution-stable luminescent dinuclear copper(I) complexes, [Cu2(μ-I)2(dpppy)2] (Cu-py) and [Cu2(μ-I)2(dpppyz)2] (Cu-pyz), where dpppy = 2,3-bis(diphenylphosphino)pyridi...

Controlled ligand distortion and its consequences for structure, symmetry, conformation and spin-state preferences of iron(ii) complexes.

The ligand-field strength in metal complexes of polydentate ligands depends critically on how the ligand backbone places the donor atoms in three-dimensional space. Distortions from regular coordinati...

Clinical Trials [420 Associated Clinical Trials listed on BioPortfolio]

Nickel Allergy and Systemic Nickel Allergy Syndrome in Non Celiac Wheat Sensitivity

In the last few years, a new clinical entity has emerged which includes patients who consider themselves to be suffering from problems caused by wheat and/or gluten ingestion, even though ...

Immediate vs. Delayed Insertion of Copper T 380A IUD After Termination of Pregnancy Over 12-Weeks Gestation

The purpose of this study is to compare delayed vs. immediate insertion of the Copper T 380 IUD after termination of pregnancy after 12 weeks.

Firewire: Investigation of the Clinical Efficiency of a Novel Orthodontic Archwire

This study protocol is for a randomised clinical trial which aims to test a new material for use as an orthodontic archwire (FireWire) compared to the current best available aligning archw...

Human Biomarkers for Assessing Copper Deficiency

Copper is an essential nutrient for humans and is cofactor in enzymes that participate in critical body functions. Insufficient copper can lead to hematological and neurological abnormali...

IMPACT STUDY: Investigating Microbial Pathogen Activity of Copper Textiles

The purpose of this study is to assess the impact of copper linens on hospital acquired infections and drug resistant bacteria.

Medical and Biotech [MESH] Definitions

Unstable isotopes of copper that decay or disintegrate emitting radiation. Cu atoms with atomic weights 58-62, 64, and 66-68 are radioactive copper isotopes.

Specific alloys not less than 85% chromium and nickel or cobalt, with traces of either nickel or cobalt, molybdenum, and other substances. They are used in partial dentures, orthopedic implants, etc.

An inherited disorder of copper metabolism transmitted as an X-linked trait and characterized by the infantile onset of HYPOTHERMIA, feeding difficulties, hypotonia, SEIZURES, bony deformities, pili torti (twisted hair), and severely impaired intellectual development. Defective copper transport across plasma and endoplasmic reticulum membranes results in copper being unavailable for the synthesis of several copper containing enzymes, including PROTEIN-LYSINE 6-OXIDASE; CERULOPLASMIN; and SUPEROXIDE DISMUTASE. Pathologic changes include defects in arterial elastin, neuronal loss, and gliosis. (From Menkes, Textbook of Child Neurology, 5th ed, p125)

A sulfate salt of copper. It is a potent emetic and is used as an antidote for poisoning by phosphorus. It also can be used to prevent the growth of algae.

A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It is caused by defects in the ATP7B gene encoding copper-transporting ATPase 2 (EC 3.6.3.4), also known as the Wilson disease protein. The overload of copper inevitably leads to progressive liver and neurological dysfunction such as LIVER CIRRHOSIS; TREMOR; ATAXIA and intellectual deterioration. Hepatic dysfunction may precede neurologic dysfunction by several years.

Quick Search
Advertisement
 


DeepDyve research library

Relevant Topic

Radiology
Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...


Searches Linking to this Article