Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region.
Summary of "Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region."
The pedunculopontine nucleus region (PPNR) is an integral component of the midbrain locomotor region and has widespread connections with the cortex, thalamus, brain stem, cerebellum, spinal cord, and especially, the basal ganglia. No previous study examined the somatosensory connection of the PPNR in human. We recorded somatosensory evoked potentials (SEP) from median nerve stimulation through deep brain stimulation (DBS) electrodes implanted in the PPNR in 8 patients (6 with Parkinson's disease, 2 with progressive supranuclear palsy). Monopolar recordings from the PPNR contacts showed triphasic or biphasic potentials. The latency of the largest negative peak was between 16.8 and 18.7 milliseconds. Bipolar derivation revealed phase reversal with median nerve stimulation contralateral to the DBS electrode in 6 patients. There was no difference in SEP amplitude and latency between on and off medication states. We also studied the high frequency oscillations (HFOs) by filtering the signal between 500 and 2,500 Hz. The HFOs could be identified only from contralateral stimulation and had intraburst frequencies of 1061 +/- 121 Hz, onset latencies of 13.8 +/- 1.2 milliseconds, and burst durations of 7.3 +/- 1.1 milliseconds. Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins. (c) 2010 Movement Disorder Society.
Affiliation
Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada.
Journal Details
This article was published in the following journal.
Name: Movement disorders : official journal of the Movement Disorder Society
ISSN: 1531-8257
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20669321
- DOI: http://dx.doi.org/10.1002/mds.23233
Medical and Biotech [MESH] Definitions
Evoked Potentials
The recorded electrical responses from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported. Often used synonymously to event-related potentials which are associated with higher level cognitive processes.
Evoked Potentials, Somatosensory
The electric response evoked in the CEREBRAL CORTEX by stimulation along AFFERENT PATHWAYS from PERIPHERAL NERVES to CEREBRUM.
Vestibular Evoked Myogenic Potentials
Recorded electrical responses from muscles, especially the neck muscles or muscles around the eyes, following stimulation of the EAR VESTIBULE.
Evoked Potentials, Auditory
The electric response evoked in the CEREBRAL CORTEX by ACOUSTIC STIMULATION or stimulation of the AUDITORY PATHWAYS.
Evoked Potentials, Visual
The electric response evoked in the cerebral cortex by visual stimulation or stimulation of the visual pathways.
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