Enhanced rho-kinase activity in circulating neutrophils of patients with vasospastic angina a possible biomarker for diagnosis and disease activity assessment.
Summary of "Enhanced rho-kinase activity in circulating neutrophils of patients with vasospastic angina a possible biomarker for diagnosis and disease activity assessment."
The aim of this study was to examine whether Rho-kinase activity is systemically enhanced in patients with vasospastic angina (VSA) and, if so, whether a noninvasive diagnostic method could be developed to improve practice.
Affiliation
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Journal Details
This article was published in the following journal.
Name: Journal of the American College of Cardiology
ISSN: 1558-3597
Pages: 1231-7
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21903056
- DOI: http://dx.doi.org/10.1016/j.jacc.2011.05.046
Medical and Biotech [MESH] Definitions
Map Kinase Kinase Kinase 5
A 150-kDa MAP kinase kinase kinase that may play a role in the induction of APOPTOSIS. It has specificity for MAP KINASE KINASE 3; MAP KINASE KINASE 4; and MAP KINASE KINASE 6.
Cdc2 Protein Kinase
Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.
Map Kinase Kinase Kinase 1
A 195-kDa MAP kinase kinase kinase with broad specificity for MAP KINASE KINASES. It is found localized in the CYTOSKELETON and can activate a variety of MAP kinase-dependent pathways.
Map Kinase Kinase Kinase 2
A 70-kDa MAP kinase kinase kinase with specificity for MAP KINASE KINASE 5. It is activated during the cellular response to GROWTH FACTORS, oxidative stress, and hyperosmotic conditions.
Fungemia
The presence of fungi circulating in the blood. Opportunistic fungal sepsis is seen most often in immunosuppressed patients with severe neutropenia or in postoperative patients with intravenous catheters and usually follows prolonged antibiotic therapy.
PubMed Articles
Background: It remains unclear whether disease activity of vasospastic angina (VSA) is altered during a disaster. Methods and Results: Before and after the Great East Japan Earthquake, we examined...
We hypothesized that Rho-kinase signaling plays a role in mechanical and adhesive mechanisms of neutrophil accumulation in lung. Male C57BL/6 mice were treated with the Rho-kinase inhibitor Y-27632 pr...
Changes and Regulation of the C5a Receptor on Neutrophils during Septic Shock in Humans.
During experimental sepsis, excessive generation of the anaphylatoxin C5a results in reduction of the C5a receptor (C5aR) on neutrophils. These events have been shown to result in impaired innate immu...
Hydroquinone (HQ) is an environmental contaminant which causes immune toxicity. In this study, the effects of exposure to low doses of HQ on neutrophil mobilization into the LPS-inflamed lung were inv...
Neutrophils are terminally differentiated cells with a short life-span due to constitutive apoptosis. Because of these characteristics, genetic manipulation of neutrophils has been difficult, although...
Clinical Trials
Effect of Glucose on Ocular Blood Flow
The primary objective is to assess the effect of glucose on retinal vascular diameter in otherwise healthy vasospastic subjects compared to non-vasospastic controls. The secondary objecti...
Hypothesis: Rho, one of the small GTPase proteins, and its downstream target molecule, Rho-kinase (ROCK), play important roles in mediating various cellular functions, including contractil...
Effect of Systemic Cooling in Vasospasms
This study tests whether women with Vasospastic Syndrome (VS) react more intensive than controls with distal vasomotions and choroidal blood flow changes to internal cooling/warming and ex...
The Effects of Atorvastatin in Patients With Atherosclerosis
The purpose of the study is to evaluate the effects of Atorvastatin. The investigators want to find out if atorvastatin has other helpful qualities. The investigators are interested in fi...
Dasatinib in Relapsed Chronic Lymphocytic Leukemia
The purpose of this research study is to see if Dasatinib is effective and safe to give to people with relapsed chronic lymphocytic leukemia (CLL) and to determine the effects of the drug...
