Kinetic characterization of a novel cationic (99m)Tc(I)-tricarbonyl complex, (99m)Tc-15C5-PNP, for myocardial perfusion imaging.
Summary of "Kinetic characterization of a novel cationic (99m)Tc(I)-tricarbonyl complex, (99m)Tc-15C5-PNP, for myocardial perfusion imaging."
BACKGROUND:
Intense liver uptake of (99m)Tc-sestamibi (MIBI) often interferes with visualization of myocardial perfusion in the inferior wall of the left ventricle. To develop improved myocardial perfusion agents, crown ether-containing dithiocarbamates and bisphosphines have been introduced in recent years. This study was designed to investigate the myocardial imaging properties and in vivo kinetics of a cationic (99m)Tc(I)-tricarbonyl complex, (99m)Tc-15C5-PNP, in comparison with MIBI.
METHODS:
Dynamic cardiac images were acquired for 60 minutes after intravenous tracer injection using a small-animal SPECT system in healthy control rats and rats with myocardial infarcts. Myocardial and liver time-activity curves were generated for radiopharmaceutical kinetic analysis.
RESULTS:
Good visualization of the left ventricular wall and perfusion defects could be achieved 20 minutes after (99m)Tc-15C5-PNP administration. (99m)Tc-15C5-PNP images in all hearts with infarcts showed perfusion defects, which were comparable to MIBI images. The kinetic curves plotted from 1 to 60 minutes demonstrated that (99m)Tc-15C5-PNP has a shorter washout half-life (6.4 +/- 3.2 vs 124 +/- 30.5 minutes, P < .01) in the liver, lower residual liver activity (14.5 +/- 10.2% vs 36.5 +/- 28.9%, P < .01), and higher heart/liver ratio than MIBI.
CONCLUSIONS:
(99m)Tc-15C5-PNP has potential for rapid myocardial perfusion imaging with low liver uptake.
Affiliation
Department of Radiology, University of Arizona, P.O. Box 245067, Tucson, AZ, 85724-5067, USA, zliu@radiology.arizona.edu.
Journal Details
This article was published in the following journal.
Name: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
ISSN: 1532-6551
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20669059
- DOI: http://dx.doi.org/10.1007/s12350-010-9262-y
Medical and Biotech [MESH] Definitions
Eosinophil Cationic Protein
One of several basic proteins released from EOSINOPHIL cytoplasmic granules. Eosinophil cationic protein is a 21-kDa cytotoxic peptide with a pI of 10.9. Although eosinophil cationic protein is considered a member of the RNAse A superfamily of proteins, it has only limited RNAse activity.
Anterior Wall Myocardial Infarction
MYOCARDIAL INFARCTION in which the anterior wall of the heart is involved. Anterior wall myocardial infarction is often caused by occlusion of the left anterior descending coronary artery. It can be categorized as anteroseptal or anterolateral wall myocardial infarction.
Cationic Amino Acid Transporter 2
A high-affinity, low capacity system y+ amino acid transporter with strong similarity to CATIONIC AMINO ACID TRANSPORTER 1. The two isoforms of the protein, CAT-2A and CAT-2B, exist due to alternative mRNA splicing. The transporter has specificity for the transport of ARGININE; LYSINE; and ORNITHINE.
Myocardial Bridging
A malformation that is characterized by a muscle bridge over a segment of the CORONARY ARTERIES. Systolic contractions of the muscle bridge can lead to narrowing of coronary artery; coronary compression; MYOCARDIAL ISCHEMIA; MYOCARDIAL INFARCTION; and SUDDEN CARDIAC DEATH.
Genotype
The genetic constitution of the individual; the characterization of the genes.
PubMed Articles
Two water soluble Re(i) tricarbonyl diimine complexes containing cationic 2,2'-bipyridyl ligands [Re(L1)(CO)(3)(AN)](2+) (1) and [Re(L2)(CO)(3)(AN)](3+) (2) (L1 and L2: a cationic 2,2'-bipyridyl ligan...
An effective one-step approach for the preparation of (porphyrinato)(phthalocyaninato) early lanthanides of type [Br(4)TPP]Ln[(15C5)(4)Pc]Ln[Br(4)TPP], where Br(4)TPP = 5,10,15,20-tetrakis-(4-bromophe...
New heteroleptic triple-decker terbium complexes of general structure [Br(4)TPP]Tb[(15C5)(4)Pc]Tb[Br(4)TPP] (Tb-TD) and [Br(4)TPP]Tb[(15C5)(4)Pc]Tb[(15C5)(4)Pc] (Tb-TD*) (Br(4)TPP = tetrakis-meso-(4-b...
A bromo tricarbonyl rhenium(i) complex with a thiophene-functionalized bis(pyrazolyl) pyridine ligand (), ReBr()(CO)(3) (), has been synthesized and characterized by variable temperature and COSY 2-D...
Two novel octamolybdate-based tricarbonyl metal derivatives have been successfully synthesized and characterized, which represent the first two examples of tricarbonyl metal groups attached to a new {...
Clinical Trials
Long Term Safety Profile of the PRO-Kinetic ENERGY Coronary Stent System in Daily Clinical Practice
To evaluate the clinical performance of the PRO-Kinetic ENERGY® coronary bare metal stent system in a patient population within that defined in the Instructions for Use.
A Study to Evaluate the Use of Stavudine (d4T) to Treat AIDS Dementia Complex
The purpose of this study is to see if adding stavudine (d4T) to anti-HIV drug regimens (with or without zidovudine, ZDV) can improve symptoms of AIDS Dementia Complex (ADC, problems invol...
Kinetic Biomarker for Chronic Lymphocytic Leukemia Prognosis
This project will attempt to validate the utilization of a stable isotope kinetic biomarker (KineMarkerTM) as a predictive test for disease progression in early stage chronic lymphocytic l...
Restore Claims Characterization Study
The purpose of this study is to characterize the pain coverage capability of the RESTORE spinal cord stimulation (SCS) and assess health outcomes.
Characterization of Local Vascular Effects of LNMMA
Characterization of an unexpected venodilative effect of higher L-NMMA-doses in dorsal human hand veins.
