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The Hypersensitive Esophagus: Pathophysiology, Evaluation, and Treatment Options.

06:00 EDT 30th July 2010 | BioPortfolio

Summary of "The Hypersensitive Esophagus: Pathophysiology, Evaluation, and Treatment Options."

Visceral hypersensitivity plays a key role in the pathogenesis of esophageal functional disorders such as functional heartburn and chest pain of presumed esophageal origin (noncardiac chest pain). About 80% of patients with unexplained noncardiac chest pain exhibit lower esophageal sensory thresholds when compared to controls during esophageal sensory testing (ie, esophageal barostat, impedance planimetry). Such information has led to prescription of peripherally and/or centrally acting therapies for the management of these patients. This review summarizes and highlights recent and significant findings regarding the pathophysiology, evaluation, and treatment of the hypersensitive esophagus, a central factor in functional esophageal disorders.

Affiliation

Laboratorio de Fisiologia Digestiva y Motilidad Gastrointestinal, Instituto de Investigaciones Medico Biologicas, Iturbide s/n, Col. Flores Magon, Veracruz, Veracruz, CP 91400, Mexico, joremes@uv.mx.

Journal Details

This article was published in the following journal.

Name: Current gastroenterology reports
ISSN: 1534-312X
Pages:

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Medical and Biotech [MESH] Definitions

A motility disorder of the ESOPHAGUS in which the LOWER ESOPHAGEAL SPHINCTER (near the CARDIA) fails to relax resulting in functional obstruction of the esophagus, and DYSPHAGIA. Achalasia is characterized by a grossly contorted and dilated esophagus (megaesophagus).

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Abnormal passage communicating with the ESOPHAGUS. The most common type is TRACHEOESOPHAGEAL FISTULA between the esophagus and the TRACHEA.

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