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Curcumin is a bioactive compound with poor oral bioavailability. Low water solubility and rapid metabolism are two known limiting factors, but the absorption mechanism of solubilized curcumin remains unclear. This study investigated the permeation mechanism of solubilized curcumin using an in vitro Caco-2 cell monolayer model. It was shown that curcumin permeated across the monolayers fairly rapidly [P(app)(A-B) = (7.1 ± 0.7) × 10(-6) cm/s] and the permeation mechanism was found as passive diffusion [P(app)(B-A)/P(app)(A-B) = 1.4]. Furthermore, the permeation rates of curcumin complexed with bovine serum albumin and in the bile salts-fatty acids mixed micelles were also determined as P(app)(mixed micelle) > P(app)(DMSO) > P(app)(protein complex). These results suggested that solubilization agents play an important role in the permeation of solubilized curcumin, and stronger binding between the solubilization agents and curcumin may decrease the permeation rate. The results further suggest that lipid-based formulations, which solubilize curcumin in mixed micelles after lipid digestion, are promising vehicles for curcumin oral delivery.
Department of Food Science, Rutgers, the State University of New Jersey , 65 Dudley Road, New Brunswick, New Jersey 08901, United States.
This article was published in the following journal.
Name: Journal of agricultural and food chemistry
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A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.
Dynamic and kinetic mechanisms of exogenous chemical and drug ABSORPTION; BIOLOGICAL TRANSPORT; TISSUE DISTRIBUTION; BIOTRANSFORMATION; elimination; and TOXICOLOGY as a function of dosage, and rate of METABOLISM. It includes toxicokinetics, the pharmacokinetic mechanism of the toxic effects of a substance. ADME and ADMET are short-hand abbreviations for absorption, distribution, metabolism, elimination and toxicology.
Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells, such as ENTEROCYTES. These cells are valuable in vitro tools for studies related to intestinal cell function and differentiation.
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
Agents that aid or increase the action of the principle drug (DRUG SYNERGISM) or that affect the absorption, mechanism of action, metabolism, or excretion of the primary drug (PHARMACOKINETICS) in such a way as to enhance its effects.
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