A 1:1 cocrystal of fluconazole with salicylic acid.
Summary of "A 1:1 cocrystal of fluconazole with salicylic acid."
The interaction of the antifungal pharmaceutical agent fluconazole with salicylic acid in acetonitrile solution yields the 1:1 cocrystal 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol-2-hydroxybenzoic acid (1/1), C(13)H(12)F(2)N(6)O·C(7)H(6)O(3). The asymmetric unit consists of one molecule of fluconazole and one molecule of salicylic acid, both in their neutral forms. Both crystal agents form head-to-tail hydrogen-bonded dimers, which are further connected into hydrogen-bonded extended zigzag tapes propagating along the ac diagonal.
Affiliation
Krka d.d., Šmarjeska cesta 6, 8501 Novo mesto, Slovenia.
Journal Details
This article was published in the following journal.
Name: Acta crystallographica. Section C, Crystal structure communications
ISSN: 1600-5759
Pages: o370-o372
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21881189
- DOI: http://dx.doi.org/10.1107/S0108270111031155
Medical and Biotech [MESH] Definitions
Salicylic Acids
Derivatives and salts of SALICYLIC ACID.
Salicylamides
Amides of salicylic acid.
Salix
A plant genus of the family SALICACEAE. Members contain salicin, which yields SALICYLIC ACID.
Salicylic Acid
A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics. (From Dorland's, 28th ed)
Salicylates
The salts, esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
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