Efficacy of Fluconazole and Nystatin in the Treatment of Vaginal Candida Species.
Summary of "Efficacy of Fluconazole and Nystatin in the Treatment of Vaginal Candida Species."
The aim of this study was to determine and compare the efficacy of treatment with fluconazole and nystatin in Brazilian women with vaginal Candida. In a population of 932 women, vaginal cultures were performed for yeasts, whether or not the women showed signs and symptoms of vulvovaginal candidiasis. Yeasts were isolated from 12.2% of the women (114/932): 53.2% of the yeasts were Candida albicans, 27.0% C. glabrata, 13.5% C. tropicalis and 6.3% C. parapsilosis. Treatment was carried out with both drugs. The overall mean cure rates with fluconazole (87.0%) and nystatin (74.0%) were similar; among women with non-albicans, the cure rate with fluconazole was 100%, whereas that with nystatin was 44.4%. The cure rate for women with C. albicans was high with both fluconazole and nystatin; however, for those with non-albicans species the cure rate was excellent with fluconazole and very low with nystatin, differing from the majority of in vitro studies.
Affiliation
Clinical Cytology Laboratory, Department of Clinical Analysis and Biomedicine, State Unversity of Maringá, Maringá, Paraná, Brazil.
Journal Details
This article was published in the following journal.
Name: Acta dermato-venereologica
ISSN: 0001-5555
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21918792
- DOI: http://dx.doi.org/10.2340/00015555-1194
Medical and Biotech [MESH] Definitions
Nystatin
Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.
Therapeutic Equivalency
The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.
Candidiasis, Invasive
An important nosocomial fungal infection with species of the genus CANDIDA, most frequently CANDIDA ALBICANS. Invasive candidiasis occurs when candidiasis goes beyond a superficial infection and manifests as CANDIDEMIA, deep tissue infection, or disseminated disease with deep organ involvement.
Candidiasis
Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)
Vaginal Smears
Collection of pooled secretions of the posterior vaginal fornix for cytologic examination.
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