DNA/protamine complex paste for an injectable dental material.
Summary of "DNA/protamine complex paste for an injectable dental material."
A DNA/protamine complex powder was prepared by reaction between DNA and protamine sulfate solution with stirring in order to develop a new injectable biomaterials for dental therapy. The powder of DNA/protamine complex became paste by kneading the complex powder and distilled water. Complex formation was confirmed by FT-IR measurement. The complex paste had a porous structure and its viscosity was approximately 280.1 Pas. The paste could easily pass through a needle of 0.25 mm internal diameter. It seemed that DNA/protamine complex paste has suitable viscosity for clinical use as an injectable biomaterial. Although, the complex paste delayed the growth speed of Staphylococcus aureus, Pseudomonas aeruginosa, Porphyromonas gingivalis and Prevotella intermedia for limited periods, it cannot kill and inhibit growing bacteria. The complex paste disk showed a mild tissue response and gradually degraded after the implantation into the soft tissue of rats. These results suggested that this DNA/protamine complex paste could be a useful material for a biodegradable biomaterial. In particular, this paste will be applicable as an injectable biomaterial using syringe for the repair of defects of living tissue, GBR treatment and/or GTR treatment in dentistry.
Affiliation
Center for Regenerative Medicine, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka, 814-0193, Japan, tadaof@college.fdcnet.ac.jp.
Journal Details
This article was published in the following journal.
Name: Journal of materials science. Materials in medicine
ISSN: 1573-4838
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21922330
- DOI: http://dx.doi.org/10.1007/s10856-011-4446-9
Medical and Biotech [MESH] Definitions
Dental Bonding
An adhesion procedure for orthodontic attachments, such as plastic DENTAL CROWNS. This process usually includes the application of an adhesive material (DENTAL CEMENTS) and letting it harden in-place by light or chemical curing.
Dental Marginal Adaptation
The degree of approximation or fit of filling material or dental prosthetic to the tooth surface. A close marginal adaptation and seal at the interface is important for successful dental restorations.
Dental Facilities
Use for material on dental facilities in general or for which there is no specific heading.
Acidulated Phosphate Fluoride
A sodium fluoride solution, paste or powder, which has been acidulated to pH 3 to 4 and buffered with a phosphate. It is used in the prevention of dental caries.
Dental Casting Investment
Material from which the casting mold is made in the fabrication of gold or cobalt-chromium castings. (Boucher's Clinical Dental Terminology, 4th ed, p168)
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