Tethered cord: natural history, surgical outcome and risk for Chiari malformation 1 (CM1) : A review of 110 detethering.

10:39 EDT 29th August 2015 | BioPortfolio

Summary of "Tethered cord: natural history, surgical outcome and risk for Chiari malformation 1 (CM1) : A review of 110 detethering."

The surgical results of this series of occult spina bifida seem better than the natural history registered in the long pre-operative period in terms of neurological deterioration. The major contribution to this result is attributed to neurophysiological monitoring that lowers the risks of permanent damage and increases the percentage of effective detethering. The present series of TCS, due to conus and filar lipoma, documents that CM1 is a really rare association occurring in less than 6% of the patients, despite the low position of conus. The detethering procedure did not influence the tonsillar position, thus excluding the correlation between the tethering and the tonsillar descent. The genetic alteration documented in a girl reinforces the hypothesis of a rare complex polymaformative picture deserving multiple procedures according to the prevailing clinical symptoms.

Affiliation

Department of Neurosurgery, Fondazione Istituto Neurologico "Carlo Besta", Via Celoria 11, 20133, Milan, Italy, lvalentini@istituto-besta.it.

Journal Details

This article was published in the following journal.

Name: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiol
ISSN: 1590-3478
Pages:

Links

PubMed Articles [25555 Associated PubMed Articles listed on BioPortfolio]

198 The Association Between Chiari Malformation Type-1 and Tethered Spinal Cord in Children.

Clinical observations of patients with both Chiari Malformation Type I (CIM) and tethered spinal cord (TSC), have led some to speculate that there may be an association between the two entities. Howev...

Surgical Treatment of Congenital Scoliosis associated with Tethered Cord by Thoracic Spine-shortening Osteotomy without Cord Detethering.

Retrospective case series.

A rare case of thoracic myelocystocele associated with type 1 split cord malformation with low lying tethered cord, dorsal syrinx and sacral agenesis: Pentad finding.

Myelocystocele is a rare form of spinal dysraphism. Thoracic myelocystocele is still rarer. The occurrence of thoracic myelocystocele associated with type-1 split cord malformation, low lying tethered...

Long-term natural outcome (7-26 years) of Lichtman stage III kienböck's Lunatomalacia.

The natural history of Kienböck's disease is controversial. Only three papers report a pure natural history without treatment. We hypothesized that the natural course of Kienböck's disease may be be...

Chiari III malformation: a comprehensive review of this enigmatic anomaly.

Chiari III is one of the rarest of the Chiari malformations and is characterized by a high cervical or low occipital encephalocele and osseous defect with or without spinal cord involvement and may in...

Clinical Trials [5236 Associated Clinical Trials listed on BioPortfolio]

Genetic Analysis of the Chiari I Malformation

The purpose of this study is to better understand the genetic factors related to the Chiari I malformation. In people with this abnormality, the lower part of the skull is smaller than no...

Chiari Study Looking at Use of Duragen Versus Duraguard

Since Chiari malformation is a common disease, many patients require surgical operation to relieve pressure from the back portion of the skull. The purpose of this research is to compare t...

Tethered Capsule Endoscope in Screening Participants for Barrett Esophagus

RATIONALE: A tethered capsule endoscope may be as effective as standard sedated endoscopy of the esophagus, stomach, and duodenum in screening for Barrett esophagus. PURPOSE: This phase I...

Duragen Versus Duraguard in Chiari Surgery

The study evaluates two materials used for duraplasty of the posterior cranial fossa in treatment of Chiari malformation. One material (DuraGen) is a non-suturable collagen matrix that is ...

The Genetics of Chiari Type I Malformation

Duke University Medical Center is investigating the hereditary basis of Chiari type I malformations with or without syringomyelia (CM1/S). Our research is aimed at learning if CM1/S is ind...

Medical and Biotech [MESH] Definitions

A former branch of knowledge embracing the study, description, and classification of natural objects (as animals, plants, and minerals) and thus including the modern sciences of zoology, botany, and mineralogy insofar as they existed at that time. In the 17th, 18th, and 19th centuries it was much used for the generalized pursuit of certain areas of science. (Webster, 3d ed; from Dr. James H. Cassedy, NLM History of Medicine Division)

A common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges. The lesion is also covered by skin. L5 and S1 are the most common vertebrae involved. The condition may be associated with an overlying area of hyperpigmented skin, a dermal sinus, or an abnormal patch of hair. The majority of individuals with this malformation are asymptomatic although there is an increased incidence of tethered cord syndrome and lumbar SPONDYLOSIS. (From Joynt, Clinical Neurology, 1992, Ch55, p34)

Surgical procedures performed through a natural opening in the body such as the mouth, nose, urethra, or anus, and along the natural body cavities with which they are continuous.

Pregnancy in which the mother and/or FETUS are at greater than normal risk of MORBIDITY or MORTALITY. Causes include inadequate PRENATAL CARE, previous obstetrical history (ABORTION, SPONTANEOUS), pre-existing maternal disease, pregnancy-induced disease (GESTATIONAL HYPERTENSION), and MULTIPLE PREGNANCY, as well as advanced maternal age above 35.

Congenital, or rarely acquired, herniation of meningeal and spinal cord tissue through a bony defect in the vertebral column. The majority of these defects occur in the lumbosacral region. Clinical features include PARAPLEGIA, loss of sensation in the lower body, and incontinence. This condition may be associated with the ARNOLD-CHIARI MALFORMATION and HYDROCEPHALUS. (From Joynt, Clinical Neurology, 1992, Ch55, pp35-6)


Advertisement
 

Relevant Topic

Spinal Cord Disorders
Latest News Clinical Trials Research Drugs Reports Corporate
The spinal cord is a bundle of nerves that runs down the middle of the back which carry signals back and forth between the body and brain. It is protected by vertebrae, which are the bone disks that make up the spine. An accident that damages the verte...

Advertisement
 

Searches Linking to this Article