Tethered cord: natural history, surgical outcome and risk for Chiari malformation 1 (CM1) : A review of 110 detethering.

06:00 EDT 17th September 2011 | BioPortfolio

Summary of "Tethered cord: natural history, surgical outcome and risk for Chiari malformation 1 (CM1) : A review of 110 detethering."

The surgical results of this series of occult spina bifida seem better than the natural history registered in the long pre-operative period in terms of neurological deterioration. The major contribution to this result is attributed to neurophysiological monitoring that lowers the risks of permanent damage and increases the percentage of effective detethering. The present series of TCS, due to conus and filar lipoma, documents that CM1 is a really rare association occurring in less than 6% of the patients, despite the low position of conus. The detethering procedure did not influence the tonsillar position, thus excluding the correlation between the tethering and the tonsillar descent. The genetic alteration documented in a girl reinforces the hypothesis of a rare complex polymaformative picture deserving multiple procedures according to the prevailing clinical symptoms.


Department of Neurosurgery, Fondazione Istituto Neurologico "Carlo Besta", Via Celoria 11, 20133, Milan, Italy,

Journal Details

This article was published in the following journal.

Name: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiol
ISSN: 1590-3478


DeepDyve research library

PubMed Articles [26319 Associated PubMed Articles listed on BioPortfolio]

Tethered cord syndrome - a study of the short term effects of surgical detethering on markers of neuronal injury and electrophysiologic parameters.

Several studies have assessed clinical and radiologic outcomes after detethering of the cord for tethered cord syndrome (TCS). However, no data regarding the impact of detethering on the metabolism or...

Management of Craniosynostosis at an Advanced Age: Controversies, Clinical Findings, and Surgical Treatment.

The natural history of unrepaired craniosynostosis is not well defined. Delayed surgical intervention carries greater risk of postoperative complications and its functional benefits for older patients...

202 Predictors of Surgical Treatment and Postoperative Complications in the Pediatric Patient With Isolated Tethered Cord Syndrome.

Isolated tethered cord syndrome (iTCS) may be diagnosed in a symptomatic patient with a low-lying conus caused by a tight and/or fatty filum. Its incidence, patient characteristics, and outcomes after...

Cervical Spondylotic Myelopathy.

Cervical spondylotic myelopathy (CSM) is a degenerative disease that represents the most common spinal cord disorder in adults. The natural history of the disease can be insidious, and patients often ...

Intraspinal Pathology Associated with Pediatric Scoliosis: A Ten-Year Review Analyzing the Effect of Neurosurgery on Scoliosis Curve Progression.

This was a retrospective study of patients with Chiari I (CM I) and II (CM II) malformations, tethered cord syndrome and syringomyelia examining the effect of neurosurgery on scoliosis.

Clinical Trials [6887 Associated Clinical Trials listed on BioPortfolio]

Genetic Analysis of the Chiari I Malformation

The purpose of this study is to better understand the genetic factors related to the Chiari I malformation. In people with this abnormality, the lower part of the skull is smaller than no...

Tethered Capsule Endoscope in Screening Patients With Barret's Esophagus

This pilot clinical trial studies how well tethered capsule endoscope works in screening patients with Barret's esophagus (BE), a condition where the lining of the esophagus has changed or...

Chiari Study Looking at Use of Duragen Versus Duraguard

Since Chiari malformation is a common disease, many patients require surgical operation to relieve pressure from the back portion of the skull. The purpose of this research is to compare t...

Duragen Versus Duraguard in Chiari Surgery

The study evaluates two materials used for duraplasty of the posterior cranial fossa in treatment of Chiari malformation. One material (DuraGen) is a non-suturable collagen matrix that is ...

Tethered Capsule Endoscope in Screening Participants for Barrett Esophagus

RATIONALE: A tethered capsule endoscope may be as effective as standard sedated endoscopy of the esophagus, stomach, and duodenum in screening for Barrett esophagus. PURPOSE: This phase I...

Medical and Biotech [MESH] Definitions

A former branch of knowledge embracing the study, description, and classification of natural objects (as animals, plants, and minerals) and thus including the modern sciences of zoology, botany, and mineralogy insofar as they existed at that time. In the 17th, 18th, and 19th centuries it was much used for the generalized pursuit of certain areas of science. (Webster, 3d ed; from Dr. James H. Cassedy, NLM History of Medicine Division)

A common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges. The lesion is also covered by skin. L5 and S1 are the most common vertebrae involved. The condition may be associated with an overlying area of hyperpigmented skin, a dermal sinus, or an abnormal patch of hair. The majority of individuals with this malformation are asymptomatic although there is an increased incidence of tethered cord syndrome and lumbar SPONDYLOSIS. (From Joynt, Clinical Neurology, 1992, Ch55, p34)

Surgical procedures performed through a natural opening in the body such as the mouth, nose, urethra, or anus, and along the natural body cavities with which they are continuous.

Pregnancy in which the mother and/or FETUS are at greater than normal risk of MORBIDITY or MORTALITY. Causes include inadequate PRENATAL CARE, previous obstetrical history (ABORTION, SPONTANEOUS), pre-existing maternal disease, pregnancy-induced disease (GESTATIONAL HYPERTENSION), and MULTIPLE PREGNANCY, as well as advanced maternal age above 35.

Congenital, or rarely acquired, herniation of meningeal and spinal cord tissue through a bony defect in the vertebral column. The majority of these defects occur in the lumbosacral region. Clinical features include PARAPLEGIA, loss of sensation in the lower body, and incontinence. This condition may be associated with the ARNOLD-CHIARI MALFORMATION and HYDROCEPHALUS. (From Joynt, Clinical Neurology, 1992, Ch55, pp35-6)

Quick Search

DeepDyve research library

Relevant Topic

Spinal Cord Disorders
The spinal cord is a bundle of nerves that runs down the middle of the back which carry signals back and forth between the body and brain. It is protected by vertebrae, which are the bone disks that make up the spine. An accident that damages the verte...

Searches Linking to this Article