Intracellular redox state as determinant for melatonin antiproliferative vs cytotoxic effects in cancer cells.
Summary of "Intracellular redox state as determinant for melatonin antiproliferative vs cytotoxic effects in cancer cells."
Abstract Melatonin is an endogenous indolamine classically known as a light/dark regulator. Besides classical functions, melatonin has also showed to have a wide range of antitumoral effects in numerous cancer experimental models. However, no definite mechanism has been described to explain the whole range of antineoplasic effects. Here we describe a dual effect of melatonin on intracellular redox state in relation to its antiproliferative vs cytotoxic actions in cancer cells. Thus, inhibition of proliferation correlates with a decrease on intracellular ROS and increase of antioxidant defenses (antioxidant enzymes and GSH levels), while induction of cell death correlates with an increase on intracellular ROS and decrease of antioxidant defenses. Moreover, cell death can be prevented by other well-known antioxidants or can be increased by hydrogen peroxide. Thus, tumor cell fate will depend on the ability of melatonin to induce either an antioxidant environment -related to the antiproliferative effect- or a prooxidant environment -related to the cytotoxic effect-.
Affiliation
Journal Details
This article was published in the following journal.
Name: Free radical research
ISSN: 1029-2470
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21923620
- DOI: http://dx.doi.org/10.3109/10715762.2011.623700
Medical and Biotech [MESH] Definitions
Receptors, Melatonin
A family of G-protein-coupled receptors that are specific for and mediate the effects of MELATONIN. Activation of melatonin receptors has been associated with decreased intracellular CYCLIC AMP and increased hydrolysis of PHOSPHOINOSITIDES.
Melatonin
A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.
Receptor, Melatonin, Mt2
A melatonin receptor subtype primarily found expressed in the BRAIN and RETINA.
Receptor, Melatonin, Mt1
A melatonin receptor subtype that is primarily found in the HYPOTHALAMUS and in the KIDNEY.
Eosinophil Major Basic Protein
One of several basic proteins released from EOSINOPHIL cytoplasmic granules. Eosinophil major basic protein is a 14-kDa cytotoxic peptide with a pI of 10.9. In addition to its direct cytotoxic effects, it stimulates the release of variety of INFLAMMATION MEDIATORS.
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