Changes in the levels of factor VIII and von Willebrand factor in the puerperium.
Summary of "Changes in the levels of factor VIII and von Willebrand factor in the puerperium."
Summary.â€‚ To determine changes in Factor VIII (FVIII) and von Willebrand Factor (VWF) in the first 3â€ƒdays of the puerperium. A prospective study assessing FVIII clotting activity, VWF activity and antigen levels in 95 women (with singleton uncomplicated pregnancies) during labour and on days 1, 2 and 3 of the puerperium. There were no significant differences in FVIII,
CB on days 1 and 2 of the puerperium compared with levels during labour. There was a significant decrease in
Ag (Pâ€ƒ=â€ƒ0.009) and
CB (Pâ€ƒ=â€ƒ0.04) on day 3. Age, ethnicity, duration of labour and mode of delivery did not have any significant effect on the changes in FVIII and VWF levels. The pregnancy induced increase in FVIII and VWF is maintained in the first 48â€ƒh after delivery. VWF levels start to decline on day 3 postdelivery.
Department of Obstetrics and Gynaecology, Royal Free Hospital, London; Haemophilia Centre and Thrombosis Unit, Royal Free Hospital, London, UK.
This article was published in the following journal.
Name: Haemophilia : the official journal of the World Federation of Hemophilia
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21951573
- DOI: http://dx.doi.org/10.1111/j.1365-2516.2011.02625.x
Medical and Biotech [MESH] Definitions
Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
Von Willebrand Factor
A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.
Deamino Arginine Vasopressin
A synthetic analog of the pituitary hormone, ARGININE VASOPRESSIN. Its action is mediated by the VASOPRESSIN receptor V2. It has prolonged antidiuretic activity, but little pressor effects. It also modulates levels of circulating FACTOR VIII and VON WILLEBRAND FACTOR.
Von Willebrand Diseases
Group of hemorrhagic disorders in which the VON WILLEBRAND FACTOR is either quantitatively or qualitatively abnormal. They are usually inherited as an autosomal dominant trait though rare kindreds are autosomal recessive. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII, and impaired platelet adhesion.
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