Detection of familial adenomatous polyposis with orthogonal polarized spectroscopy of the oral mucosa vasculature.
Summary of "Detection of familial adenomatous polyposis with orthogonal polarized spectroscopy of the oral mucosa vasculature."
Familial Adenomatous Polyposis (FAP) is an autosomal dominant disease characterized by the development of multiple colonic polyps at younger age with a near 100% lifetime risk of colorectal cancer. The determination of FAP is made after extensive clinical evaluation and genetic testing of at risk individuals. We investigated a novel spectro-polarimetric imaging system capable of capturing high-resolution images of the oral mucosa at different wavelengths in an attempt to distinguish patients with FAP from controls. Results of a clinical trial show that the system is capable of separating FAP positive individuals from controls by measuring the individuals' oral vascular density and complexity. (© 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim).
Affiliation
The Catholic University of America, 620 Michigan Ave NE, Washington DC, USA.
Journal Details
This article was published in the following journal.
Name: Journal of biophotonics
ISSN: 1864-0648
Pages: 707-14
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21922674
- DOI: http://dx.doi.org/10.1002/jbio.201100057
Medical and Biotech [MESH] Definitions
Genes, Apc
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.
Adenomatous Polyposis Coli Protein
A negative regulator of beta-catenin signaling which is mutant in ADENOMATOUS POLYPOSIS COLI and GARDNER SYNDROME.
Gardner Syndrome
A variant of ADENOMATOUS POLYPOSIS COLI caused by mutation in the APC gene (GENES, APC) on CHROMOSOME 5. It is characterized by not only the presence of multiple colonic polyposis but also extracolonic ADENOMATOUS POLYPS in the UPPER GASTROINTESTINAL TRACT; the EYE; the SKIN; the SKULL; and the FACIAL BONES; as well as malignancy in organs other than the GI tract.
Adenomatous Polyposis Coli
A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. The lifetime risk of colorectal cancer in these patients reaches 100 percent by age 60.
Electron Spin Resonance Spectroscopy
A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.
PubMed Articles
The aim of the study was to identify the causative gene defects associated with familial adenomatous polyposis (FAP) in two Chinese pedigrees.
Hepatoblastoma in two siblings and familial adenomatous polyposis: causal nexus or coincidence?
Infantile and childhood hepatoblastoma (HB) occurs more frequently in children with hereditary predisposition to familial adenomatous polyposis (FAP) than in the general population. The occurrence of...
Rectal cancers in patients with familial adenomatous polyposis.
Patients with familial adenomatous polyposis may develop rectal cancer at their initial presentation (primary) or after colectomy and ileorectal anastomosis (secondary). Little is known about whether...
The other colonic polyposis syndromes.
Familial colorectal cancer syndromes have been increasingly recognized and through their characterization have contributed to our understanding of the genetic basis of colorectal cancer. The two main...
Familial adenomatous polyposis (FAP) is an autosomal dominant disorder which typically presents with colorectal cancer in early adult life, secondary to extensive adenomatous polyps of the colon. In a...
Clinical Trials
Curcumin for Treatment of Intestinal Adenomas in Familial Adenomatous Polyposis (FAP)
The purpose of the study is to assess if curcumin, a natural plant extract and spice, can regress colorectal and duodenal adenomatous polyps in patients with familial adenomatous polyposis...
Use of Curcumin in the Lower Gastrointestinal Tract in Familial Adenomatous Polyposis Patients
The purpose of this study is to assess if curcumin, a commonly used food spice, can regress colorectal adenomatous polyps in patients with familial adenomatous polyposis, an inherited form...
Trial In Pediatric Patients With Familial Adenomatous Polyposis (FAP)
To test whether celecoxib can be used to prevent colon polyp formation in children with familial adenomatous polyposis (FAP).
Multimedia Intervention in Patients With Familial Adenomatous Polyposis (FAP)
The goal of this research study is to test the first version of a website that will offer information and support for adolescents and young adults with familial adenomatous polyposis (FAP...
Malignant transformation of adenomas of the duodenum is now the leading cause of death in familial adenomatous polyposis (FAP) patients who had a restorative proctocolectomy. Ursodeoxychol...
