Poorly Differentiated Thyroid Carcinoma. Are We There Yet?
Summary of "Poorly Differentiated Thyroid Carcinoma. Are We There Yet?"
The article reviews the controversial area of poorly differentiated thyroid carcinoma. Consensus criteria that define poorly differentiated thyroid carcinoma have been published in 2007. According to these, poorly differentiated thyroid carcinoma is a distinct histotype and the term "poorly differentiated" should not be used as a synonym for high-grade thyroid cancer. Data in the literature show that tumor necrosis and high mitotic activity, but not growth pattern or histologic subtype, are prognostic markers for thyroid tumors. This underscores the importance of grading to identify thyroid carcinomas that behave aggressively. The issue of grading versus typing thyroid tumors is discussed.
Affiliation
Bologna University School of Medicine, Bologna, Italy, giovanni.tallini@ausl.bologna.it.
Journal Details
This article was published in the following journal.
Name: Endocrine pathology
ISSN: 1559-0097
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21969055
- DOI: http://dx.doi.org/10.1007/s12022-011-9176-5
Medical and Biotech [MESH] Definitions
Carcinoma, Ehrlich Tumor
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.
Carcinoma, Signet Ring Cell
A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Carcinoma, Neuroendocrine
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Peanut Agglutinin
Lectin purified from peanuts (ARACHIS HYPOGAEA). It binds to poorly differentiated cells and terminally differentiated cells and is used in cell separation techniques.
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