A Marine Carotenoid, Fucoxanthin, Induces Regulatory T Cells and Inhibits Th17 Cell Differentiation in Vitro.

09:53 EDT 30th September 2014 | BioPortfolio

Summary of "A Marine Carotenoid, Fucoxanthin, Induces Regulatory T Cells and Inhibits Th17 Cell Differentiation in Vitro."

Fucoxanthin is a non-provitamin A carotenoid contained in brown seaweeds. We found that it suppressed interleukin-17 secretion from CD4(+) T cells under IL-17-producing T (Th17) cell development conditions. By evaluating T cell differentiation in vitro, fucoxanthin and its metabolite fucoxanthinol inhibited T cell differentiation into Th17 cells. This suggests that fucoxanthin can improve inflammatory diseases due to Th17 cells.

Affiliation

Research and Development Division, Kikkoman Corporation.

Journal Details

This article was published in the following journal.

Name: Bioscience, biotechnology, and biochemistry
ISSN: 1347-6947
Pages:

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A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.

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Predominantly marine algae of the division Phaeophyta, having CHROMATOPHORES containing carotenoid PIGMENTS, BIOLOGICAL. ALGINATES and phlorotannins occur widely in all major orders. They are considered the most highly evolved algae because of their well-developed multicellular organization and structural complexity.

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