Analysis of fetal chromosomal karyotype and etiology in 252 cases of early spontaneous abortion.
Summary of "Analysis of fetal chromosomal karyotype and etiology in 252 cases of early spontaneous abortion."
OBJECTIVE:
To investigate the relationship between fetal chromosomal karyotype and early spontaneous abortion, and the effect of the environmental factors on spontaneous abortion.
METHODS:
Choronic villi from 252 cases of missed abortion were sampled as patient group and 50 normal pregnancies as control group. Chorionic villi were cultured and karyotype analysis was performed by G-banding. Clinical information was collected.
RESULTS:
The rate of chorion chromosome abnormality in the patient group was 58.09%, significantly higher than that in the control group (4.17%) (P<0.01). Among the 140 cases of karyotype abnormalities, 81 were trisomy, 29 were monosomy X and 17 were polyploidy, accounting for 57.86%, 20.71% and 12.14% of total abnormalities, respectively. Long time and low dose radiation exposure of the pregant female seemed to be related with spontaneous abortion(P<0.01).
CONCLUSION:
Chorion chromosome abnormality is a major reason of early spontaneous abortion and karyotype analysis of chorionic villus is of clinical importantce. For pregnant women, long-term exposure to computers and television seems a risk factor for missed abortion.
Affiliation
Central Laboratory of Shenzhen Maternity and Child Healthcare Hospital Affiliated to Southern Medical University, Shenzhen, Guangdong, 518000 P. R. China. jianshengxie2000@yahoo.com.cn.
Journal Details
This article was published in the following journal.
Name: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
ISSN: 1003-9406
Pages: 575-578
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21983739
- DOI: http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2011.05.024
Medical and Biotech [MESH] Definitions
Amniocentesis
Percutaneous transabdominal puncture of the uterus during pregnancy to obtain amniotic fluid. It is commonly used for fetal karyotype determination in order to diagnose abnormal fetal conditions.
Nuchal Cord
A complication of pregnancy in which the UMBILICAL CORD wraps around the fetal neck once or multiple times. In some cases, cord entanglement around fetal neck may not affect pregnancy outcome significantly. In others, the nuchal cord may lead to restricted fetal blood flow, oxygen transport, fetal development, fetal movement, and complicated delivery at birth.
Casuistry
A method of ETHICAL ANALYSIS that emphasizes practical problem solving through examining individual cases that are considered to be representative; sometimes used to denote specious argument or rationalization. Differentiate from casuistics, which is the recording and study of cases and disease.
Fetal Distress
A nonreassuring fetal status (NRFS) indicating that the FETUS is compromised (American College of Obstetricians and Gynecologists 1988). It can be identified by sub-optimal values in FETAL HEART RATE; oxygenation of FETAL BLOOD; and other parameters.
Gonadoblastoma
A complex neoplasm composed of a mixture of gonadal elements, such as large primordial GERM CELLS, immature SERTOLI CELLS or GRANULOSA CELLS of the sex cord, and gonadal stromal cells. Gonadoblastomas are most often associated with abnormal chromosomal karyotype, GONADAL DYSGENESIS, and the presence of a Y CHROMOSOME.
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