Management of glucocorticoid induced hyperglycemia.
Summary of "Management of glucocorticoid induced hyperglycemia."
Glucocorticoid-induced hyperglycemia is a frequent problem. In the general clinical practice, it may generate hospital admissions, their prolongation and repeated emergency visits without obtaining an adequate solution to the problem. Even so, this problem continues to be undervalued in terms of diagnosis, and especially, treatment. The diversity of preparations and dosing schedules of corticosteroids, and above all, the low level of involvement by the professionals who prescribe steroids and the absence of clinical studies and specific recommendations for diagnosis and treatment, contribute to this. In this paper we review the pathophysiology of glucocorticoid-induced hyperglycemia and propose some strategies for their management, based on the clinical situation and the predictable pattern of hyperglycemia according to the type and schedule of glucocorticoids administration.
Servicio de Endocrinología y Nutrición, Consorci Hospitalari de Vic, Barcelona, España.
This article was published in the following journal.
Name: Revista clinica espanola
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20667527
- DOI: http://dx.doi.org/10.1016/j.rce.2010.03.006
Medical and Biotech [MESH] Definitions
A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS.
Glucocorticoid-induced Tnfr-related Protein
A member of the TNF receptor family that was initially identified as a DEXAMETHASONE-induced protein from a T-CELL line. It may play a role in regulating APOPTOSIS and modulating immune response by T-lymphocytes. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)
Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.
Materials Management, Hospital
The management of all procurement, distribution, and storage of equipment and supplies, as well as logistics management including laundry, processing of reusables, etc.
: Provide treatment guidelines for glucocorticoid-induced hyperglycemia and to understand the clinical implications of glucocorticoid-induced hyperglycemia.
Pharmacologic doses of glucocorticoids and chronic renal failure are challenging comorbidities and complications for safe and effective dosing of insulin for the management of hospitalized patients wi...
The present investigation provides mechanistic insights into the hyperglycemic and stressogenic effects of monocrotophos, an organophosphorus insecticide. Pre-treatment of rats with mifepristone (gluc...
Objective The aim of this study was to evaluate the adherence of guidelines for the management and treatment of glucocorticoid-induced osteoporosis, and to investigate whether it is associated with fa...
This paper provides a framework for the development of national guidelines for the management of glucocorticoid-induced osteoporosis in men and women aged 18 years and over in whom oral glucocorticoi...
Osteoporosis is a condition in which the amount of bone is reduced, the bones are weak, and there is an increased risk for fractures. Glucocorticoids (such as prednisone) are prescribed t...
The purpose of this study is to explore whether the GLP-1 receptor agonist exenatide, may prevent glucocorticoid-induced glucometabolic abnormalities and beta-cell dysfunction in healthy s...
The investigators will assess whether the DPP-inhibitor sitagliptin will ameliorate glucocorticoid-induced impairment of glucose metabolism and beta-cell dysfunction and thus could be used...
A growing body of evidence suggests hyperglycemia is associated with adverse outcomes in patients with and without diabetes. Observational studies document an association between hypergly...
This 2 arm study will investigate the efficacy and safety of Bonviva (150mg po monthly) in the prevention of glucocorticoid-induced osteoporosis in post-menopausal women. Patients will be...