Intensity of cytosol expression of 8-OHdG in normal renal tubules is associated with the severity of renal fibrosis.
Summary of "Intensity of cytosol expression of 8-OHdG in normal renal tubules is associated with the severity of renal fibrosis."
It has been proposed that reactive oxygen species play a role in renal fibrosis. 8-OHdG, a metabolite of oxidative damage to leukocyte DNA, has been identified as a marker of oxidative stress in patients with chronic renal failure.
Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital, No. 110, Section 1, Jianguo N. Road, Taichung 402, TW. email@example.com.
This article was published in the following journal.
Name: Swiss medical weekly
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21989970
- DOI: http://dx.doi.org/10.4414/smw.2011.13268
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Medical and Biotech [MESH] Definitions
A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.
A condition characterized by calcification of the renal tissue itself. It is usually seen in distal RENAL TUBULAR ACIDOSIS with calcium deposition in the DISTAL KIDNEY TUBULES and the surrounding interstitium. Nephrocalcinosis causes RENAL INSUFFICIENCY.
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A group of inherited kidney disorders characterized by the abnormally elevated levels of AMINO ACIDS in URINE. Genetic mutations of transport proteins result in the defective reabsorption of free amino acids at the PROXIMAL RENAL TUBULES. Renal aminoaciduria are classified by the specific amino acid or acids involved.
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