Transcobalamin 2 variant associated with poststroke homocysteine modifies recurrent stroke risk.
Summary of "Transcobalamin 2 variant associated with poststroke homocysteine modifies recurrent stroke risk."
The Vitamin Intervention for Stroke Prevention trial found an association between baseline poststroke homocysteine (Hcy) and recurrent stroke. We investigated genes for enzymes and cofactors in the Hcy metabolic pathway for association with Hcy and determined whether associated single nucleotide polymorphisms (SNPs) influenced recurrent stroke risk.
Affiliation
Center for Public Health Genomics, University of Virginia, PO Box 800717, Charlottesville, VA 22908 msale@virginia.edu.
Journal Details
This article was published in the following journal.
Name: Neurology
ISSN: 1526-632X
Pages: 1543-50
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21975197
- DOI: http://dx.doi.org/10.1212/WNL.0b013e318233b1f9
Medical and Biotech [MESH] Definitions
Homocysteine S-methyltransferase
An enzyme that catalyzes the demethylation of L-homocysteine to L-METHIONINE.
5-methyltetrahydrofolate-homocysteine S-methyltransferase
An enzyme that catalyzes the formation of methionine by transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine. It requires a cobamide coenzyme. The enzyme can act on mono- or triglutamate derivatives. EC 2.1.1.13.
Betaine-homocysteine S-methyltransferase
A ZINC metalloenzyme that catalyzes the transfer of a methyl group from BETAINE to HOMOCYSTEINE to produce dimethylglycine and METHIONINE, respectively. This enzyme is a member of a family of ZINC-dependent METHYLTRANSFERASES that use THIOLS or selenols as methyl acceptors.
Hyperhomocysteinemia
Condition in which the plasma levels of homocysteine and related metabolites are elevated (>13.9 μmol/l). Hyperhomocysteinemia can be familial or acquired. Development of the acquired hyperhomocysteinemia is mostly associated with vitamins B and/or folate deficiency (e.g., PERNICIOUS ANEMIA, vitamin malabsorption). Familial hyperhomocysteinemia often results in a more severe elevation of total homocysteine and excretion into the urine, resulting in HOMOCYSTINURIA. Hyperhomocysteinemia is a risk factor for cardiovascular and neurodegenerative diseases, osteoporotic fractures and complications during pregnancy.
Melkersson-rosenthal Syndrome
An idiopathic syndrome characterized by one or more of the following; recurrent orofacial swelling, relapsing facial paralysis, and fissured tongue (lingua plicata). The onset is usually in childhood and relapses are common. Cheilitis granulomatosa is a monosymptomatic variant of this condition. (Dermatol Clin 1996 Apr;14(2):371-9; Magalini & Magalini, Dictionary of Medical Syndromes, 4th ed, p531)
PubMed Articles
Background/Objectives:Methionine synthase catalyzes the conversion of 5-methyltetrahydrofolate to tetrahydrofolate and homocysteine (Hcy) to methionine using vitamin B(12) as a cofactor. Transcobalami...
Poststroke depression and treatment effects on functional outcomes.
Poststroke depression (PSD) is common after stroke; however, the relationship to poststroke function is inconclusive. Our objectives were to 1) determine the relationship between PSD at baseline (1 mo...
BACKGROUND: Vitamin B12, holo-haptocorrin and the folate-pathway single-nucleotide polymorphisms (SNPs) MTR 2756A>G and SHMT1 1420C>T have been associated with an increased risk of prostate cancer. We...
Hyperhomocysteinemia, C677T MTHFR Polymorphism And Ischemic Stroke In Tunisian Patients.
Background: Hyperhomocysteinaemia has been identified as a strong risk factor for ischemic stroke (IS). A point mutation in methylene tetrahydrofolate reductase (MTHFR C677T) has been associated with...
Role, indications, and controversies of antidepressant therapy in chronic stroke patients.
Antidepressants are a heterogeneous class of drugs that have been developed for the treatment of mood disorders. In the past several years, they have been used in poststroke survivors to treat poststr...
Clinical Trials
Elevation of plasma homocysteine has been recognized as one of the risk factors of atherosclerotic disease. The objectives of this study are: (1) to investigate the level of plasma homocys...
Study of Homocysteine Metabolism in Homocystinuria
OBJECTIVES: I. Determine basal and postmethionine plasma homocysteine in patients with premature vascular disease, cystathionine beta-synthase (CBS) or methylenetitrahydrofolate reductase...
Study on the Influence of Electroconvulsive Therapy (ECT) on Homocysteine Levels
Elevated homocysteine levels are associated with depression and cognitive impairment. When depression ameliorates due to treatment, homocysteine serum levels often normalize. Aim of the pr...
Effect of S-adenosylmethionine (SAMe) on Blood Levels of Homocysteine
The purpose of this study is to investigate whether S-adenosylmethionine (SAMe), a natural substance available as a nutritional supplement, can influence blood levels of homocysteine (Hcy)...
This open label, non-interventional study is to show the efficacy of Pulmicort®Respules® in cough variant asthma in patient aged 5-year old or younger in outpatient department
