Efficacy and safety of mifepristone and buccal misoprostol versus buccal misoprostol alone for medical abortion.
Summary of "Efficacy and safety of mifepristone and buccal misoprostol versus buccal misoprostol alone for medical abortion."
To evaluate the efficacy and safety of mifepristone and buccal misoprostol versus buccal misoprostol alone in medical abortion of â‰¤56Â days. STUDY
One hundred pregnant women having gestational age â‰¤56Â days were randomized to group A and group B. In group A, patients received 200Â mg mifepristone on day 1, followed by buccal misoprostol 800Â Âµg on day 2, and in group B patients received 800Â Âµg buccal misoprostol only on day 1. MAIN OUTCOME
Complete abortion was the principal outcome measure. Secondary outcome measures were side-effects and acceptability.
Forty-six (92%) patients in group A and 37 (74%) patients in group B aborted successfully (p value 0.017). Four (8%) patients in group A and eight (16%) patients in group B had incomplete abortion with retained products of conception. In group B, three (6%) patients had missed abortion and two (4%) patients had continued pregnancy whereas none of the patients in group A had missed abortion or continued pregnancy. The overall method acceptance was 100% whereas the overall route acceptance was 83%.
Misoprostol-alone regimen is a low-cost regimen as compared to mifepristone/misoprostol regimen. Though the efficacy of mifepristone followed by buccal misoprostol is better, buccal misoprostol alone can be used for termination of pregnancy in patients where mifepristone is either unavailable or contraindicated.
, 74-R, Model Town, Rohtak, 124001, Haryana, India, email@example.com.
This article was published in the following journal.
Name: Archives of gynecology and obstetrics
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22009509
- DOI: http://dx.doi.org/10.1007/s00404-011-2110-8
Medical and Biotech [MESH] Definitions
Administration of a soluble dosage form between the cheek and gingiva. It may involve direct application of a drug onto the buccal mucosa, as by painting or spraying.
A synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties.
A suborder of protozoa characterized by peniculi, which are often situated deep in the buccal cavity, and by fusiform trichocysts.
A superfamily of nematodes of the suborder CAMALLANINA. Its organisms possess a poorly developed buccal cavity and a rudimentary esophagus and intestine.
Excision of the apical portion of a tooth through an opening made in the overlying labial, buccal, or palatal alveolar bone. (Dorland, 28th ed)
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