Efficacy and safety of mifepristone and buccal misoprostol versus buccal misoprostol alone for medical abortion.
Summary of "Efficacy and safety of mifepristone and buccal misoprostol versus buccal misoprostol alone for medical abortion."
OBJECTIVES:
To evaluate the efficacy and safety of mifepristone and buccal misoprostol versus buccal misoprostol alone in medical abortion of ≤56 days. STUDY
DESIGN:
One hundred pregnant women having gestational age ≤56 days were randomized to group A and group B. In group A, patients received 200 mg mifepristone on day 1, followed by buccal misoprostol 800 µg on day 2, and in group B patients received 800 µg buccal misoprostol only on day 1. MAIN OUTCOME
MEASURES:
Complete abortion was the principal outcome measure. Secondary outcome measures were side-effects and acceptability.
RESULTS:
Forty-six (92%) patients in group A and 37 (74%) patients in group B aborted successfully (p value 0.017). Four (8%) patients in group A and eight (16%) patients in group B had incomplete abortion with retained products of conception. In group B, three (6%) patients had missed abortion and two (4%) patients had continued pregnancy whereas none of the patients in group A had missed abortion or continued pregnancy. The overall method acceptance was 100% whereas the overall route acceptance was 83%.
CONCLUSION:
Misoprostol-alone regimen is a low-cost regimen as compared to mifepristone/misoprostol regimen. Though the efficacy of mifepristone followed by buccal misoprostol is better, buccal misoprostol alone can be used for termination of pregnancy in patients where mifepristone is either unavailable or contraindicated.
Affiliation
, 74-R, Model Town, Rohtak, 124001, Haryana, India, krishnadahiya@rediffmail.com.
Journal Details
This article was published in the following journal.
Name: Archives of gynecology and obstetrics
ISSN: 1432-0711
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22009509
- DOI: http://dx.doi.org/10.1007/s00404-011-2110-8
Medical and Biotech [MESH] Definitions
Administration, Buccal
Administration of a soluble dosage form between the cheek and gingiva. It may involve direct application of a drug onto the buccal mucosa, as by painting or spraying.
Misoprostol
A synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties.
Peniculina
A suborder of protozoa characterized by peniculi, which are often situated deep in the buccal cavity, and by fusiform trichocysts.
Dracunculoidea
A superfamily of nematodes of the suborder CAMALLANINA. Its organisms possess a poorly developed buccal cavity and a rudimentary esophagus and intestine.
Apicoectomy
Excision of the apical portion of a tooth through an opening made in the overlying labial, buccal, or palatal alveolar bone. (Dorland, 28th ed)
PubMed Articles
Objective?To evaluate the efficacy and safety of home administration of buccal misoprostol after mifepristone for medical abortion up to 70 days' gestation in a general practice in Cura?ao, where indu...
Randomized trial of oral versus sublingual misoprostol 24 h after mifepristone for medical abortion.
OBJECTIVES: To assess the efficacy, side effects, and acceptability of medical abortion using oral mifepristone (200 mg) followed 24 h later by oral or sublingual misoprostol (400 mug). MATERIALS AND...
Objective To examine the efficacy, acceptability and feasibility of early medical abortion, with the option of home administration of misoprostol, in Uzbekistan. Methods A total of 450 women were enro...
OBJECTIVE: To compare the safety, efficacy, and acceptability of 400-mug sublingual misoprostol with that of manual vacuum aspiration (MVA) in 2 Egyptian hospitals. METHODS: Participating women were r...
OBJECTIVE: To compare the efficacy of 1-day and 2-day mifepristone and misoprostol intervals for second trimester termination of pregnancy between 13 and 16weeks. METHODS: A prospective randomized coh...
Clinical Trials
This double-blind, randomized study will compare the efficacy and acceptability of mifepristone 200mg followed in 36-48 hours by 400mcg or 800mcg of buccal misoprostol (i.e., in the cheeks...
This open-label, randomized study will compare the efficacy, safety, and acceptability of mifepristone 200 mg followed in 24-36 hours either by buccal (i.e., in the cheeks) or oral misopro...
The Extended Gestational Age Medical Abortion Study
This open-label, comparative study will compare the efficacy, safety, and acceptability of 200 mg mifepristone followed in 24-48 hours by 800mcg buccal misoprostol or 400mcg sublingual mis...
The purpose of this study is to determine the effectiveness of buccal misoprostol and comparing this with vaginal route of the same drug.
The primary goal of this study is to determine the clinical advantage of pre-treatment with mifepristone in second trimester misoprostol induction abortion. This will be a randomized contr...
