Trauma-associated hyperfibrinolysis.
Summary of "Trauma-associated hyperfibrinolysis."
Trauma-induced coagulopathy (TIC) has been considered for a long time as being due to depletion of coagulation factors secondary to blood loss, dilution and consumption. Dysfunction of the remaining coagulation factors due to hypothermia and acidosis is assumed to additionally contribute to TIC. Recent data suggest that hyperfibrinolysis (HF) represents an additional important confounder to the disturbed coagulation process. Severe shock and major tissue trauma are the main drivers of this HF. The incidence of HF is still speculative. According to visco-elastic testing of trauma patients upon emergency room admission, HF is present in approximately 2.5-7% of all trauma patients. However, visco-elastic tests provide information on severe forms of HF only. Occult HF seems to be much more common but diagnosis is still challenging. Results from a recent randomized, placebo-controlled trial suggest that the early treatment of trauma patients with tranexamic acid may result in a significant reduction of trauma-associated mortality.
Affiliation
Dr. Herbert Schöchl, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstr. 13, 1200 Vienna, Austria, E-mail: herbert.schoechl@trauma.lbg.ac.at, Tel. +43/664 34 22 945, Fax +43/6217 20279.
Journal Details
This article was published in the following journal.
Name: Hamostaseologie
ISSN: 0720-9355
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22009115
- DOI: http://dx.doi.org/10.5482/ha-1178
Medical and Biotech [MESH] Definitions
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Specialized hospital facilities which provide diagnostic and therapeutic services for trauma patients.
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Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)
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Systems for assessing, classifying, and coding injuries. These systems are used in medical records, surveillance systems, and state and national registries to aid in the collection and reporting of trauma.
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Dysfunction of one or more cranial nerves causally related to a traumatic injury. Penetrating and nonpenetrating CRANIOCEREBRAL TRAUMA; NECK INJURIES; and trauma to the facial region are conditions associated with cranial nerve injuries.
Abducens Nerve Injury
Traumatic injury to the abducens, or sixth, cranial nerve. Injury to this nerve results in lateral rectus muscle weakness or paralysis. The nerve may be damaged by closed or penetrating CRANIOCEREBRAL TRAUMA or by facial trauma involving the orbit.
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