Track topics on Twitter Track topics that are important to you
Background and Methods:â€‚ From the time that Sinatra etÂ al. (Anesthesiology. 2005;102:822) was published to FDA apaproval of intravenous (IV) acetaminophen, an expanded analysis of the original raw study data became necessary for the regulatory submission. The following analyses were conducted: (1) sum of pain intensity differences over 24â€ƒhours (SPID24) using currently accepted imputation methods to account for both missing data and the effects of rescue; (2) efficacy results after the first 6â€ƒhours; (3) effects of gender, race/ethnicity, age, weight, surgical site, ASA Class, and serotonin antagonists; and (4) a stepwise regression analysis of why adverse events of nausea and vomiting were numerically (although not statistically) higher in the IV acetaminophen group compared with placebo. Results:â€‚ Sum of pain intensity differences over 24â€ƒhours using a 0- to 100-mm visual analog scale was statistically significantly (Pâ€ƒ<â€ƒ0.001) in favor of IV acetaminophen (nâ€ƒ=â€ƒ49) compared with placebo (nâ€ƒ=â€ƒ52). Time to rescue was found to be 3.9 and 2.1â€ƒhours, respectively, for total hip and knee arthroplasty compared with 0.8â€ƒhours for the placebo group. Rescue medication consumption, requests, and actual administration were all significantly lower in the IV acetaminophen group compared with placebo for each dosing interval, except in the 6- to 12-hours interval where a numerical trend was observed. Analysis of various subset variables demonstrated similar efficacy for each variable. A stepwise regression analysis demonstrated that AE reports of nausea and vomiting were most likely due to prerandomization events, particularly opioid consumption and presence of nausea prior to randomization. Conclusion:â€‚ Repeated-dose 24-hours end points were found to be as robust as previously published results. IV acetaminophen efficacy and safety appeared to be unaffected by specific subset variables.â–ª
Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut, U.S.A. Department of Anesthesiology, David Geffen School of Medicine at UCLA, Ronald Reagan UCLA Medical Center, Los Angeles, California, U.S.A.
This article was published in the following journal.
Name: Pain practice : the official journal of World Institute of Pain
Acetaminophen is a nonsteroidal, nonsalicylate analgesic and antipyretic that is, today, the most common medication ingredient found in oral and rectal over-the-counter and prescription drugs. However...
This article aims to discuss and provide insight into the effects of the increased use and price (from $12.43 to $35.40 in 2014) of intravenous acetaminophen, which has rapidly gained acceptance in th...
To assess the role of intravenous acetaminophen (IVA) in orbital surgery.
Acetaminophen is a commonly used pediatric medication that has recently been approved for intravenous use in the United States. The purpose of this article was to review the pharmacodynamics, indicati...
Acetaminophen (APAP) consumption is large and sometimes excessive, and guidelines suggest to diminish the dosage prescription. In emergency situations of mild/moderate pain intravenous (iv) APAP is re...
This study will compare IV (intravenous) versus oral (PO) acetaminophen for postoperative pain after scheduled, elective Cesarean delivery. All patients will receive a standardized spinal ...
Uncontrolled pain after posterior fossa surgery and associated negative side effects of conventional opioid therapy causes significant morbidity and mortality in infants and children. Intr...
This study will be investigating the efficacy and safety administration of multiple doses of IV Acetaminophen in the 48 hour period following Gynecologic Surgery. The research hypothesis ...
Current standard of care for post-operative analgesia after breast surgery in CDHA is Tylenol #3Â® (300 mg acetaminophen, 30 mg codeine, 15 mg caffeine per tablet). We are proposing to tes...
Many patients with cancer pain have pain not fully controlled on opioids (eg. morphine). The addition of acetaminophen (Tylenol) to opioids in a small study in cancer patients demonstrated...
Nonexpendable items used in the performance of orthopedic surgery and related therapy. They are differentiated from ORTHOTIC DEVICES, apparatus used to prevent or correct deformities in patients.
Surgical procedures conducted with the aid of computers. This is most frequently used in orthopedic and laparoscopic surgery for implant placement and instrument guidance. Image-guided surgery interactively combines prior CT scans or MRI images with real-time video.
A condition of persistent pain and discomfort in the BACK and the LEG following lumbar surgery, often seen in patients enrolled in pain centers.
Pain during the period after surgery.
Devices which are used in the treatment of orthopedic injuries and diseases.
Pain is defined by the International Association for the Study of Pain as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage”. Some illnesses can be excruci...
Arthroplasty Joint Disorders Orthopedics Spinal Cord Disorders Orthopedics is the science or practice of correcting deformities caused by disease or damage to the bones and joints of the skeleton. This specialized branch of surgery may ...
use of tylenol iv in ortho surgerywhy Iv tylenol is used after surgerynurse suspended after using tylenol iv dripnurse suspended after using tylenol iv dripiv tylenol for postoperative ortho painbio csl iv pain portfoliobio csl iv pain portfolioiv tylenol major orthopedicssinatra IV APAP study summarywhy give iv tylenol after surgeryiv tylenol for postoperative ortho painiv tylenol for postoperative ortho painiv tylenol for postoperative ortho painpost surgery IV tylenoliv acetaminophen and joint surgery