Neurosarcoidosis: Diagnosis and Management.
Summary of "Neurosarcoidosis: Diagnosis and Management."
Sarcoidosis is a multisystemic inflammatory granulomatous disease that affects both the central and peripheral nervous system. The neurological manifestations depend on the areas of the neuroaxis affected. In the brain, patients with neurosarcoidosis have leptomeningeal and intraparenchymal infiltration of granulomas that leads to, for example, cranial nerve palsies, basal meningitis, and endocrine dysfunction. It can cause peripheral neuropathies such as mononeuritis multiplex and sensorimotor polyneuropathy as well as radiculopathy and myopathy. Diagnosis and management of patients with neurosarcoidosis are challenging given that the gold standard is tissue-proven biopsy, which, in most cases of neurological illness, is difficult to obtain. Treatment strategies have not been rigorously evaluated but corticosteroids are considered the drug of choice. Other immunosuppressant agents such as cyclophosphamide, mycophenolate mofetil, and infliximab are efficacious in the treatment of neurosarcoidosis.
Affiliation
Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland.
Journal Details
This article was published in the following journal.
Name: Seminars in respiratory and critical care medicine
ISSN: 1098-9048
Pages: 419-427
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20665392
- DOI: http://dx.doi.org/10.1055/s-0030-1262210
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