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A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in the presence of a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, 1 inhibited the quorum sensing-regulated pyocyanin production and biofilm formation in Pseudomonas aeruginosa PAO1. These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further.
Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya , 50603 Kuala Lumpur, Malaysia.
This article was published in the following journal.
Name: Journal of natural products
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A phenomenon where microorganisms communicate and coordinate their behavior by the accumulation of signaling molecules. A reaction occurs when a substance accumulates to a sufficient concentration. This is most commonly seen in bacteria.
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A plant species in the MYRISTICACEAE family. The seed is used as a spice and used for antimicrobial and psychoactive effects. Myristicin, SAFROLE, and methyleugenol are key components.
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