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Malabaricone C from Myristica cinnamomea Exhibits Anti-Quorum Sensing Activity.

Summary of "Malabaricone C from Myristica cinnamomea Exhibits Anti-Quorum Sensing Activity."

A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in the presence of a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, 1 inhibited the quorum sensing-regulated pyocyanin production and biofilm formation in Pseudomonas aeruginosa PAO1. These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further.

Affiliation

Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya , 50603 Kuala Lumpur, Malaysia.

Journal Details

This article was published in the following journal.

Name: Journal of natural products
ISSN: 1520-6025
Pages: 2261-4

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