Investigation of the effect of hyperglycemia on intracerebral hemorrhage by proteomic approaches.
Summary of "Investigation of the effect of hyperglycemia on intracerebral hemorrhage by proteomic approaches."
Intracerebral hemorrhage (ICH) is associated with high mortality and disability, and hyperglycemia worsens the clinical and neurological outcomes of patients with ICH. In this study, we utilized proteomic approaches to investigate the role of hyperglycemia in ICH. Hyperglycemia was induced by intraperitoneal injection of streptozotocin (STZ) in adult Sprague-Dawley male rats; ICH was induced by stereotaxic infusion of collagenase/heparin into the right striatum. It was observed that the size of induced hemorrhage was significantly larger in the hyperglycemic group (n=6 in each group). On the first day after ICH, an apparent decrease of the bilateral grasp was also observed for the lesioned hyperglycemic rats compared with normoglycemic ones. When employing 2-DE and MS to examine the proteomes of perihematomal and control regions in individual hyperglycemic and normoglycemic rats, eight differentially expressed protein targets were identified. Most noteworthy, in response to ICH significant increase of albumin was ubiquitously observed in the brains of normoglycemic rats but not in the brains of hyperglycemic rats. Coincidentally, more significant neuronal apoptosis were found in the perihematomal regions of hyperglycemic rats. These observations described suggest the protection role of albumin in acute stage of ICH, which may dependent on different blood sugar levels.
Affiliation
Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan; Department of Neurosurgery, Taichung Tzu Chi General Hospital, Taichung, Taiwan; Department of Neurosurgery, Taichung Hospital, Taichung, Taiwan.
Journal Details
This article was published in the following journal.
Name: Proteomics
ISSN: 1615-9861
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22065606
- DOI: http://dx.doi.org/10.1002/pmic.201100256
Medical and Biotech [MESH] Definitions
Chronotherapy
The adaptation of therapeutic approaches such as pharmacological (DRUG CHRONOTHERAPY), surgical, radiological, or physical to the known variations in biological RHYTHMICITY, such as CIRCADIAN RHYTHMS. The treatment is aimed at supporting normal rhythms, or modifying the timing of therapy to achieve maximal efficacy and minimal adverse effect.
Placebo Effect
An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.
Confounding Factors (epidemiology)
Factors that can cause or prevent the outcome of interest, are not intermediate variables, and are not associated with the factor(s) under investigation. They give rise to situations in which the effects of two processes are not separated, or the contribution of causal factors cannot be separated, or the measure of the effect of exposure or risk is distorted because of its association with other factors influencing the outcome of the study.
Retrobulbar Hemorrhage
Hemorrhage within the orbital cavity, posterior to the eyeball.
Eye Hemorrhage
Intraocular hemorrhage from the vessels of various tissues of the eye.
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