The fallacy of reduction.
Summary of "The fallacy of reduction."
Rewers M. The fallacy of reduction. The "accelerator hypothesis" has made a significant impact on research into the etiology of type 1 diabetes. Some, but not all prospective studies have confirmed a weak association between insulin resistance and faster progression to diabetes among persons with advanced islet autoimmunity. However, there is hardly any evidence that insulin resistance can cause development of islet autoimmunity, thus be responsible for the ongoing pandemic of type 1 diabetes in children.
Affiliation
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, USA.
Journal Details
This article was published in the following journal.
Name: Pediatric diabetes
ISSN: 1399-5448
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22059463
- DOI: http://dx.doi.org/10.1111/j.1399-5448.2011.00832.x
Medical and Biotech [MESH] Definitions
Risk Reduction Behavior
Reduction of high-risk choices and adoption of low-risk quantity and frequency alternatives.
Caloric Restriction
Reduction in caloric intake without reduction in adequate nutrition. In experimental animals, caloric restriction has been shown to extend lifespan and enhance other physiological variables.
Post-exercise Hypotension
Transient reduction in blood pressure levels immediately after exercises that lasts 2-12 hours. The reduction varies but is typically 5-20 mm Hg when compared to pre-exercise levels. It exists both in normotensive and hypertensive individuals and may play a role in excercise related PHYSIOLOGIC ADAPTATION.
Thioredoxins
Hydrogen-donating proteins that participates in a variety of biochemical reactions including ribonucleotide reduction and reduction of PEROXIREDOXINS. Thioredoxin is oxidized from a dithiol to a disulfide when acting as a reducing cofactor. The disulfide form is then reduced by NADPH in a reaction catalyzed by THIOREDOXIN REDUCTASE.
Harm Reduction
The application of methods designed to reduce the risk of harm associated with certain behaviors without reduction in frequency of those behaviors. The risk-associated behaviors include ongoing and active addictive behaviors.
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