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Hadjivassiliou M, Wallis LI, Hoggard N, Grünewald RA, Griffiths PD, Wilkinson ID. MR spectroscopy and atrophy in Gluten, Friedreich's and SCA6 ataxias. Acta Neurol Scand:
10.1111/j.1600-0404.2011.01620.x. © 2011 John Wiley & Sons A/S. Background - Previous work using proton MR spectroscopy ((1) H-MRS) of the cerebellum in the ataxias suggested that (1) H-MRS abnormalities and atrophy do not necessarily occur concurrently. Aims - To investigate the spectroscopic features of different types of ataxias. Methods - Using a clinical MR system operating at 1.5T, we performed (1) H-MRS with a single voxel placed over the right dentate nucleus in 22 patients with gluten ataxia (GA), six patients with Friedreich's ataxia (FA), six patients with spinocerebellar ataxia type 6 (SCA6) and 21 healthy volunteers. Atrophy of the vermis and hemispheres on standard MRI was rated by a neuroradiologist. Any interaction between atrophy and (1) H-MRS was analysed for the three groups of patients and controls. Results - Patients with GA had significant atrophy of the vermis and hemispheres as well as abnormal (1) H-MRS. Patients with SCA6 had more severe overall atrophy of the vermis and hemispheres, but relatively preserved N-acetyl-aspartate/creatine (NAA/Cr). The FA group showed significant atrophy of only the superior vermis with normal (1) H-MRS. Conclusions - This study suggests that (1) H-MRS of the cerebellum in patients with ataxia provides information in addition to the presence of atrophy. There are significant (1) H-MRS differences amongst different types of ataxia with interesting correlations between atrophy and NAA/Cr.
Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK Department of Academic Neuroradiology, Royal Hallamshire Hospital, Sheffield, UK.
This article was published in the following journal.
Name: Acta neurologica Scandinavica
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