Medial septal area ANG II receptor subtypes in the regulation of urine and sodium excretion induced by vasopressin.
Summary of "Medial septal area ANG II receptor subtypes in the regulation of urine and sodium excretion induced by vasopressin."
INTRODUCTION:
The present study was designed to determine the effects of selective antagonists of angiotensin II receptor types AT1 and AT2 on the flow of urine and sodium excretion induced by arginine vasopressin (AVP). MATERIALS AND
METHODS:
To this end, the drugs were microinjected into the medial septal area (MSA) of the brains of male Holtzman rats. Intravenous infusion of hypotonic saline was used to promote urinary flow, which was collected for one hour.
RESULTS:
MSA microinjections of AVP decreased the urinary flow and increased sodium excretion in a dose-dependent manner. Microinjection into MSA of an AT2 antagonist (PD-123319) had a significantly greater effect than with an AT1 antagonist (losartan) in increasing urinary flow and decreasing sodium excretion. These effects were more pronounced when both antagonists were injected together, before the AVP.
CONCLUSIONS:
These results indicate that MSA AT1 and AT2 receptors act synergistically in the regulation of urine and sodium excretion induced by AVP.
Affiliation
Department of Clinical Analysis, São Paulo State University (UNESP) at Araraquara (SP), Brazil.
Journal Details
This article was published in the following journal.
Name: Journal of the renin-angiotensin-aldosterone system : JRAAS
ISSN: 1752-8976
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20663845
- DOI: http://dx.doi.org/10.1177/1470320310375584
Medical and Biotech [MESH] Definitions
Septum Of Brain
Gray matter structures of the telencephalon and limbic system in the brain, but containing widely varying definitions among authors. Included here is the cortical septal area, subcortical SEPTAL NUCLEI, and the SEPTUM PELLUCIDUM. Many authorities consider the septal region to be made up of the septal area and the septal nuclei, but excluding the septum pellucidum. (Anthoney, Neuroanatomy and the Neurologic Exam, 1994, pp485-489; NeuroNames, http://rprcsgi.rprc.washington.edu/neuronames/index.html (November 18, 1998)).
Septal Nuclei
Neural nuclei situated in the septal region. They have afferent and cholinergic efferent connections with a variety of forebrain and brainstem areas including the hippocampus, the lateral hypothalamus, the tegmentum, and the amygdala. Included are the dorsal, lateral, medial, and triangular septal nuclei, septofimbrial nucleus, nucleus of diagonal band, nucleus of anterior commissure, and the nucleus of stria terminalis.
Double Outlet Right Ventricle
Incomplete transposition of the great vessels in which both the AORTA and the PULMONARY ARTERY arise from the RIGHT VENTRICLE. The only outlet of the LEFT VENTRICLE is a large ventricular septal defect (VENTRICULAR SEPTAL DEFECTS or VSD). The various subtypes are classified by the location of the septal defect, such as subaortic, subpulmonary, or noncommitted.
Hypothalamic Area, Lateral
This area is bounded medially by the mammillothalamic tract and the anterior column of fornix. The medial edge of the internal capsule and the subthalamic region form its lateral boundary. It contains the lateral hypothalamic nucleus, tuberomammillary nucleus, lateral tuberal nuclei, and fibers of the MEDIAL FOREBRAIN BUNDLE. (Parent, Carpenter's Human Neuroanatomy, 9th ed, p710)
Diagonal Band Of Broca
Cholinergic bundle of nerve fibers posterior to the anterior perforated substance. It interconnects the paraterminal gyrus in the septal area with the hippocampus and lateral olfactory area.
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