The use of high doses of OROS hydromorphone in an acute palliative care unit.
Summary of "The use of high doses of OROS hydromorphone in an acute palliative care unit."
Abstract Objectives: To characterize patients who received high doses of OROS hydromorphone (OROD-HY), a retrospective study of patients admitted in an acute pain relief and palliative care unit for a period of two years (from June 2009 to June 2011) was performed. Methods: Globally, 79 patients were prescribed OROS-HY during admission at mean maximum doses of 68?mg/day (?42). Twenty-two patients were switched from other opioids to OROS-HY and 16 patients were switched from OROS-HY to other opioids. Sixty-three patients were discharged home with a prescription of OROS-HY with doses of 53?mg/day (?44). Doses were significantly lower in older patients (p?0.005). The mean admission time was 6.1 days (?3.2). During admission 10 patients (12.6%) were prescribed doses of OROS-HY of more than 64?mg/day. Results: The maximum mean doses of this group of patients reached during admission were 238?mg/day. Eight of them were successfully treated and discharged home with doses of 175?mg/day. Two patients did not achieve an adequate balance between analgesia and adverse effects and received alternative treatments. Conclusion: This study demonstrated that OROS-HY administered in larger doses was relatively safe and effective, showing versatility and flexibility similar to other opioids.
Affiliation
Journal Details
This article was published in the following journal.
Name: Current medical research and opinion
ISSN: 1473-4877
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22077957
- DOI: http://dx.doi.org/10.1185/03007995.2011.628982
Medical and Biotech [MESH] Definitions
Coronary Care Units
The hospital unit in which patients with acute cardiac disorders receive intensive care.
Palliative Care
Care alleviating symptoms without curing the underlying disease. (Stedman, 25th ed)
Apache
An acronym for Acute Physiology and Chronic Health Evaluation, a scoring system using routinely collected data and providing an accurate, objective description for a broad range of intensive care unit admissions, measuring severity of illness in critically ill patients.
Tachyphylaxis
Rapidly decreasing response to a drug or physiologically active agent after administration of a few doses. In immunology, it is the rapid immunization against the effect of toxic doses of an extract or serum by previous injection of small doses. (Dorland, 28th ed)
Hospices
Facilities or services which are especially devoted to providing palliative and supportive care to the patient with a terminal illness and to the patient's family.
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