Bovine paratuberculosis: recent advances in vaccine development.
Summary of "Bovine paratuberculosis: recent advances in vaccine development."
Bovine paratuberculosis is a highly prevalent chronic infection of the small intestine in cattle, caused by Mycobacterium avium subspecies paratuberculosis. Current control strategies based on test-and-cull and biosecurity measures do not suffice in lowering the prevalence of paratuberculosis in an adequate manner. Therefore, control programmes are in need of an effective vaccine, but at the moment no vaccine is registered for use in cattle in the European Union. This review provides a brief overview of the microbiology, epidemiology and immunology of bovine paratuberculosis, and focuses on recent advances in the development of vaccines against paratuberculosis.
Affiliation
a Department of Infectious Diseases and Immunology , Immunology Division, Utrecht University , Utrecht , The Netherlands.
Journal Details
This article was published in the following journal.
Name: The Veterinary quarterly
ISSN: 0165-2176
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22077785
- DOI: http://dx.doi.org/10.1080/01652176.2011.633766
Medical and Biotech [MESH] Definitions
Paratuberculosis
A chronic GASTROENTERITIS in RUMINANTS caused by MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS.
Education, Dental, Continuing
Educational programs designed to inform dentists of recent advances in their fields.
Education, Nursing, Continuing
Educational programs designed to inform nurses of recent advances in their fields.
Education, Medical, Continuing
Educational programs designed to inform physicians of recent advances in their field.
Education, Pharmacy, Continuing
Educational programs designed to inform graduate pharmacists of recent advances in their particular field.
PubMed Articles
The purpose of this investigation was to characterise the virulence of two Mycobacterium avium subspecies paratuberculosis (M.a. paratuberculosis) vaccine strains and compare them with a recent virule...
Improved Outlook on HIV-1 Prevention and Vaccine Development.
Introduction: The development of an effective vaccine against HIV-1 has been challenging but recent advances in both the HIV prevention landscape and the partial efficacy of the recent RV144 vaccine e...
Recent advances in HIV vaccine development have created a renaissance in the search for a safe and effective HIV vaccine. These advances include the first demonstration in human clinical trials of a v...
Mycobacterium avium subsp. paratuberculosis heat shock protein 70 (MAPHsp70) is an immunodominant antigen, which can be used as a subunit vaccine against bovine paratuberculosis. In the present study,...
Mycobacterium avium subspecies paratuberculosis (MAP) causes a chronic intestinal infection of ruminants and has been associated with the etiology of human Crohn's disease. A MAP Hsp70/DDA subunit vac...
Clinical Trials
Safety and Immunogenicity Study of the Tetravalent Rotavirus Vaccine
A double blind placebo controlled Phase I/II study to evaluate the safety and immunogenicity of the Live Attenuated Tetravalent (G1-G4) Bovine-Human Reassortant Rotavirus Vaccine [BRV-TV]i...
To determine the reactivity and safety of HIV-1 recombinant envelope glycoprotein gp160. To determine the immunogenicity of gp160. Although recent advances have been made in antiviral the...
Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract. The origin of Crohn's disease remains unknown and there is no curative therapy, either medical or surgica...
A randomized, double-blind, placebo-controlled, staged dosage escalation study to evaluate the safety, tolerability, and immunogenicity of a 3-dose series of Live Attenuated Tetravalent (G...
Safety and Efficacy of Bovine Milk Immunoglobulin Against CS17 and CsbD
This is a Phase II, randomized, double-blind, placebo-controlled study designed to investigate whether hyperimmune bovine milk IgG products specific for CsbD and CS17, protect subjects aga...