Proteasome inhibitors suppress expression of NPM and ARF proteins.

06:00 EST 11th November 2011 | BioPortfolio

Summary of "Proteasome inhibitors suppress expression of NPM and ARF proteins."

Proteasome inhibitors stabilize numerous proteins by inhibiting their degradation. Previously we have demonstrated that proteasome inhibitors thiostrepton, MG132 and bortezomib paradoxically inhibit transcriptional activity and mRNA/protein expression of FOXM1. Here we demonstrate that, in addition to FOXM1, the same proteasome inhibitors also decrease mRNA and protein expression of NPM and ARF genes. These data suggest that proteasome inhibitors may suppress gene expression by stabilizing their transcriptional inhibitors.


Department of Medicine; University of Illinois at Chicago; Chicago, IL USA.

Journal Details

This article was published in the following journal.

Name: Cell cycle (Georgetown, Tex.)
ISSN: 1551-4005


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Medical and Biotech [MESH] Definitions

The act of ligating UBIQUITINS to PROTEINS to form ubiquitin-protein ligase complexes to label proteins for transport to the PROTEASOME ENDOPEPTIDASE COMPLEX where proteolysis occurs.

Compounds that suppress or block the plasma membrane transport of GAMMA-AMINOBUTYRIC ACID by GABA PLASMA MEMBRANE TRANSPORT PROTEINS.

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