Prevention of HIV-1 Infection with Antiretroviral Therapy.
Summary of "Prevention of HIV-1 Infection with Antiretroviral Therapy."
To the Editor: To recommend antiretroviral therapy (ART) as a policy to prevent transmission of the human immunodeficiency virus type 1 (HIV-1), it is critical to understand the risk of transmission through sex without condom use when the plasma viral load in patients receiving ART is fully suppressed. In addition to data reported by Cohen et al. (Aug. 11 issue),(1) a 2009 meta-analysis(2) showed no transmissions in 291 person-years, and the Partners in Prevention Study (ClinicalTrials.gov number, NCT00194519)(3) showed one transmission in 273 person-years, but some couples used condoms. Accounting for the proportions of couples having sex without the use . . .
Affiliation
Journal Details
This article was published in the following journal.
Name: The New England journal of medicine
ISSN: 1533-4406
Pages: 1934-1935
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22087689
- DOI: http://dx.doi.org/10.1056/NEJMc1110588#SA2
Medical and Biotech [MESH] Definitions
Hiv-associated Lipodystrophy Syndrome
Defective metabolism leading to fat maldistribution in patients infected with HIV. The etiology appears to be multifactorial and probably involves some combination of infection-induced alterations in metabolism, direct effects of antiretroviral therapy, and patient-related factors.
Antiretroviral Therapy, Highly Active
Drug regimens, for patients with HIV INFECTIONS, that aggressively suppress HIV replication. The regimens usually involve administration of three or more different drugs including a protease inhibitor.
Primary Prevention
Specific practices for the prevention of disease or mental disorders in susceptible individuals or populations. These include HEALTH PROMOTION, including mental health; protective procedures, such as COMMUNICABLE DISEASE CONTROL; and monitoring and regulation of ENVIRONMENTAL POLLUTANTS. Primary prevention is to be distinguished from SECONDARY PREVENTION and TERTIARY PREVENTION.
Secondary Prevention
The prevention of recurrences or exacerbations of a disease that already has been diagnosed. This also includes prevention of complications or after-effects of a drug or surgical procedure.
Medication Therapy Management
Assistance in managing and monitoring drug therapy for patients receiving treatment for cancer or chronic conditions such as asthma and diabetes, consulting with patients and their families on the proper use of medication; conducting wellness and disease prevention programs to improve public health; overseeing medication use in a variety of settings.
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