Concurrent stimulation-induced place preference in lateral hypothalamus and parabrachial complex: differential effects of naloxone.
Summary of "Concurrent stimulation-induced place preference in lateral hypothalamus and parabrachial complex: differential effects of naloxone."
Place preference induction by intracerebral electrical stimulation was initially shown by Olds and Milner. It has since proven possible to induce concurrent stimulation-induced place preference (cCPP) after electrical stimulation of the lateral hypothalamus (LH) and, more recently, of the external lateral parabrachial nucleus (LPBe). The objective of this experimental study was to examine whether the rewarding effects of electrical stimulation of the LH and LPBe involve the activation of similar opioid systems in an alternative cCPP task. Administration of the opioid antagonist naloxone (4mg/kg) blocked the conditioned place preference effect induced after LPBe but not after LH stimulation (at 4 or 10mg/kg). These results are interpreted in relation to the presence of multiple reward systems that might anatomically and neurochemically differ with respect to the involvement of the opioid system.
Psychobiology, University of Granada, Campus of Cartuja s/n, Granada 18071, Spain. email@example.com
This article was published in the following journal.
Name: Behavioural brain research
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21807032
- DOI: http://dx.doi.org/10.1016/j.bbr.2011.07.029
Medical and Biotech [MESH] Definitions
Neural nuclei situated in the septal region. They have afferent and cholinergic efferent connections with a variety of forebrain and brainstem areas including the hippocampus, the lateral hypothalamus, the tegmentum, and the amygdala. Included are the dorsal, lateral, medial, and triangular septal nuclei, septofimbrial nucleus, nucleus of diagonal band, nucleus of anterior commissure, and the nucleus of stria terminalis.
The part of the hypothalamus posterior to the middle region consisting of several nuclei including the medial mamillary nucleus, lateral mamillary nucleus, and posterior hypothalamic nucleus (posterior hypothalamic area). The posterior hypothalamic area is concerned with control of sympathetic responses and is sensitive to conditions of decreasing temperature and controls the mechanisms for the conservation and increased production of heat.
Ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle.
Stimulation of the brain, which is self-administered. The stimulation may result in negative or positive reinforcement.
Anterior Hypothalamic Nucleus
Loose heterogeneous collection of cells in the anterior hypothalamus, continuous rostrally with the medial and lateral preoptic areas and caudally with the tuber cinereum.
Changes in phosphorylation of CREB, ERK, and c-fos induction in rat ventral tegmental area, hippocampus and prefrontal cortex after conditioned place preference induced by chemical stimulation of lateral hypothalamus.
Experimental evidence indicates that chemical stimulation of lateral hypothalamus (LH) by carbachol can produce conditioned place preference (CPP) in rats. Several lines of evidence have shown that cA...
The activation of protease-activated receptor 1 (PAR1) in cultured rat hippocampal neurons triggers synaptic retrograde signaling through the endocannabinoid 2-arachidonoylglycerol, thereby activating...
The polyamine agmatine modulates a variety of behavioral effects including the abuse-related effects of opioids and has been proposed as a potential medication candidate for the treatment of opioid ab...
The present study investigated the subnuclear organization of collateralized efferent projection patterns from the mouse parabrachial nucleus (PbN), the second taste relay in rodents, to higher gustat...
We investigated the role of histone H3 phosphoacetylation in the nucleus accumbens (NAc) in heroin-conditioned place preference paradigm. Heroin could dose-dependently increase histone H3 phosphoacety...
The main objective of this study is to examine the effects of magnetic stimulation on the prefrontal cortex. We plan to use low frequency, repeated transcranial magnetic stimulation (1 Hz...
Alzheimer's Disease (AD) is the most common cause of dementia for which no treatment has shown consistent efficacy to stop or slow down the disease. Recent report of enhancement of memory...
The purpose of this multicenter study is to determine if insulin-like growth factor-1 (IGF-I) slows the progressive weakness in amyotrophic lateral sclerosis (ALS) patients. Study particip...
The aim of this study is to evaluate the efficacy and safety of deep brain stimulation (DBS) in chronic and treatment-resistant CH. Inclusion criteria are: patients with chronic CH (>3year...
Parkinson' disease is a neurodegenerative disorder characterised by bradykinesia, rigidity, rest tremor and postural instability. Dopaminergic therapy such as L-Dopa and dopamine agonists...