Concurrent stimulation-induced place preference in lateral hypothalamus and parabrachial complex: differential effects of naloxone.
Summary of "Concurrent stimulation-induced place preference in lateral hypothalamus and parabrachial complex: differential effects of naloxone."
Place preference induction by intracerebral electrical stimulation was initially shown by Olds and Milner. It has since proven possible to induce concurrent stimulation-induced place preference (cCPP) after electrical stimulation of the lateral hypothalamus (LH) and, more recently, of the external lateral parabrachial nucleus (LPBe). The objective of this experimental study was to examine whether the rewarding effects of electrical stimulation of the LH and LPBe involve the activation of similar opioid systems in an alternative cCPP task. Administration of the opioid antagonist naloxone (4mg/kg) blocked the conditioned place preference effect induced after LPBe but not after LH stimulation (at 4 or 10mg/kg). These results are interpreted in relation to the presence of multiple reward systems that might anatomically and neurochemically differ with respect to the involvement of the opioid system.
Affiliation
Psychobiology, University of Granada, Campus of Cartuja s/n, Granada 18071, Spain. mjsimon@ugr.es
Journal Details
This article was published in the following journal.
Name: Behavioural brain research
ISSN: 1872-7549
Pages: 311-6
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21807032
- DOI: http://dx.doi.org/10.1016/j.bbr.2011.07.029
Medical and Biotech [MESH] Definitions
Septal Nuclei
Neural nuclei situated in the septal region. They have afferent and cholinergic efferent connections with a variety of forebrain and brainstem areas including the hippocampus, the lateral hypothalamus, the tegmentum, and the amygdala. Included are the dorsal, lateral, medial, and triangular septal nuclei, septofimbrial nucleus, nucleus of diagonal band, nucleus of anterior commissure, and the nucleus of stria terminalis.
Hypothalamus, Posterior
The part of the hypothalamus posterior to the middle region consisting of several nuclei including the medial mamillary nucleus, lateral mamillary nucleus, and posterior hypothalamic nucleus (posterior hypothalamic area). The posterior hypothalamic area is concerned with control of sympathetic responses and is sensitive to conditions of decreasing temperature and controls the mechanisms for the conservation and increased production of heat.
Hypothalamus
Ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle.
Self Stimulation
Stimulation of the brain, which is self-administered. The stimulation may result in negative or positive reinforcement.
Anterior Hypothalamic Nucleus
Loose heterogeneous collection of cells in the anterior hypothalamus, continuous rostrally with the medial and lateral preoptic areas and caudally with the tuber cinereum.
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