Mitochondrial involvement in carbachol-induced intracellular Ca(2+) mobilization and contraction in rat gastric smooth muscle.

19:51 EDT 28th March 2015 | BioPortfolio

Summary of "Mitochondrial involvement in carbachol-induced intracellular Ca(2+) mobilization and contraction in rat gastric smooth muscle."

Mitochondria are important modulators of Ca(2+) homeostasis. However, it is not clear if they modulate and participate in smooth muscle signaling and contraction. The aim of the present work was to investigate the role of mitochondria in Ca(2+) transients and contraction induced by metabotropic muscarinic receptor activation in rat gastric smooth muscle.

Affiliation

Department of Pharmacology, Paulista School of Medicine, Federal University of São Paulo (UNIFESP/EPM), Brazil.

Journal Details

This article was published in the following journal.

Name: Life sciences
ISSN: 1879-0631
Pages: 757-64

Links

PubMed Articles [16974 Associated PubMed Articles listed on BioPortfolio]

Cyanidin-3-glucoside Inhibits ATP-induced Intracellular Free Ca(2+) Concentration, ROS Formation and Mitochondrial Depolarization in PC12 Cells.

Flavonoids have an ability to suppress various ion channels. We determined whether one of flavonoids, cyanidin-3-glucoside, affects adenosine 5'-triphosphate (ATP)-induced calcium signaling using digi...

The role of nNOS and PGC-1α in skeletal muscle cells.

Neuronal nitric oxide synthase (nNOS) and peroxisome proliferator activated receptor γ co-activator 1α (PGC-1α) are two fundamental factors involved in the regulation of skeletal muscle cell metabo...

Diadenosine tetraphosphate contributes to carbachol-induced tear secretion.

The purpose of this study is to investigate if the cholinergic stimulation by carbachol on tear secretion is a direct process or if it is also mediated by purinergic mechanisms. Experiments were perfo...

NAMPT regulates mitochondria biogenesis via NAD metabolism and calcium binding proteins during skeletal muscle contraction.

The purpose of this study was to investigate the effect that muscle contraction induced NAD metabolism via NAMPT has on mitochondrial biogenesis.

The nitric oxide donor cis-ru(bpy)2(SO3)NO(PF6) increases gastric mucosa protection in mice- involvement of the soluble guanylate cyclase /KATP pathway.

Here, we have evaluated the protective effect of the NO donor cis-[Ru(bpy)2(SO3)NO](PF6) (FOR0810) in experimental models of gastric damage induced by naproxen or ethanol in mice, and the involvement ...

Clinical Trials [2332 Associated Clinical Trials listed on BioPortfolio]

Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow

To investigate headache score and accompanying symptoms during and after infusion of carbachol.

Insulin Sensitizers on Mitochondrial ATP Production and Mitochondrial ATP Production and Mitochondrial Protein Synthesis on Insulin Resistant Type 2 Diabetes and Obesity

An association between insulin resistance and mitochondrial dysfunction has been observed in aging, T2D, and in offspring of patients with T2D. It remains to be determined whether pharmac...

Carbachols Headache-inducing Effect and Changes in Cerebral Blood Flow in Migraine Patients

The purpose of this study is to test if carbachol infusion induces headache in migraine subjects as well as intra- and extra-cerebral vasodilatation.

Assessment of Pulmonary Involvement inUlcerative Colitis by Induced Sputum

Ulcerative colitis is a systemic disease we assume that extra intestinal involvement as we describein our study( Fireman Z, Osipov A, Kivity S, Kopelman Y, Sternberg A Fireman E: Assessmen...

Abdominal Adiposity and Muscle Mitochondrial Functions

Numerous studies have demonstrated that excess perivisceral adipose tissue is associated with metabolic diseases such as insulin resistance. In skeletal muscle, insulin resistance has bee...

Medical and Biotech [MESH] Definitions

A synthetic methylprostaglandin E1 analog that reduces gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the therapy of gastric ulcers and gives significant protection against NSAID-induced gastric mucosal damage. The drug also prevents cyclosporin A-induced damage to endocrine and exocrine pancreatic secretions. It shows a low order of acute toxicity and there is no evidence of embryotoxicity, fetotoxicity, teratogenicity, or mutagenicity in animal studies.

Artificially induced UTERINE CONTRACTION. Generally, LABOR, OBSTETRIC is induced with the intent to cause delivery of the fetus and termination of pregnancy.

Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.

Abnormal distention of the STOMACH due to accumulation of gastric contents that may reach 10 to 15 liters. Gastric dilatation may be the result of GASTRIC OUTLET OBSTRUCTION; ILEUS; GASTROPARESIS; or denervation.

A subclass of purinergic P2Y receptors that have a preference for ATP and ADP. The activated P2Y1 receptor signals through the G-PROTEIN-coupled activation of PHOSPHOLIPASE C and mobilization of intracellular CALCIUM.

Search BioPortfolio:
Loading
Advertisement

Relevant Topic

Rheumatology
Latest News Clinical Trials Research Drugs Reports Corporate
Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Dictionary). It is an active area of medical research, because of the d...

Advertisement

Searches Linking to this Article