Sirtuin 1 in immune regulation and autoimmunity.

Summary of "Sirtuin 1 in immune regulation and autoimmunity."

The NAD-dependent histone deacetylase sirtuin (Sirt)1 is implicated in a wide variety of physiological processes, ranging from tumorigenesis to mitochondrial biogenesis to neuronal development. Recent studies indicate that Sirt1 is a critical regulator of both the innate and adaptive immune response in mice and its altered functions are likely involved in autoimmune diseases. Small molecules that modulate Sirt1 functions are potential therapeutic reagents for autoimmune inflammatory diseases. In this review, we highlight the functions of Sirt1 in the immune system focusing on the underlying molecular mechanisms, and the potential of Sirt1 as a therapeutic target for autoimmune diseases.Immunology and Cell Biology advance online publication, 22 November 2011; doi:10.1038/icb.2011.102.


Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Journal Details

This article was published in the following journal.

Name: Immunology and cell biology
ISSN: 1440-1711


DeepDyve research library

PubMed Articles [10153 Associated PubMed Articles listed on BioPortfolio]

Cellular and molecular mechanisms of immune dysregulation and autoimmunity.

Primary immunodeficiencies (PIDs) constitute a large group of rare disorders that affect the function of the immune system. A specific group of PIDs entitled "diseases of immune dysregulation" are dev...

A link: Allergic rhinitis, Asthma & Systemic Lupus Erythematosus.

This review has discussed a link between allergic rhinitis, asthma and systemic lupus erythematosus (SLE) and a case report in this area. A clear link with symptoms of allergic rhinitis, asthma and SL...

Who watches the watchmen? Regulation of the expression and activity of sirtuins.

Sirtuins (SIRT1-7) are a family of nicotine adenine dinucleotide (NAD(+))-dependent enzymes that catalyze post-translational modifications of proteins. Together, they regulate crucial cellular functio...

Regulation of the T Cell Response by CD39.

The ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1, or CD39) catalyzes the phosphohydrolysis of extracellular ATP (eATP) and ADP (eADP) released under conditions of inflammatory stress and c...

Regulation of Autoimmunity by the Microbiome.

Intestinal microbes have profound effects on inflammatory autoimmunity in sites distant from the gut. The mechanisms whereby this happens are only now beginning to be understood and may include such d...

Clinical Trials [2677 Associated Clinical Trials listed on BioPortfolio]

Analysis of B Cells From Autoimmune Individuals

This observational study aims at finding out if individual with autoimmunity exhibit increased numbers of B cells that express two types (instead of one type) of antibodies, and if B cells...

Association of Thyroid Autoimmunity and Chronic Urticaria

Increase prevalence of thyroid autoimmunity is found in patients with chronic urticaria. About 5-34% of chronic urticaria patients is associated with the presence of thyroid autoimmunity w...

Thyroid Autoimmunity and Reproductive Failure in Danish Women

The present Ph.D.-study investigates the mechanisms behind the association between thyroid autoimmunity and reproductive failure.

Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg)

Recent research studies of early onset-obsessive compulsive disorder (OCD) and Tourette's syndrome have questioned whether autoimmunity could play a role in the development of these condit...

Physiological Effects of Altering Cancer-related Inflammation

This prospective pilot study will examine whether the previously reported effects of NSAIDs on colorectal cancer may be modulated through alterations in tissue gene expression, up regulati...

Medical and Biotech [MESH] Definitions

Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES.

A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in gene regulation.

A sirtuin family member found primarily in the CYTOPLASM. It is a multifunctional enzyme that contains a NAD-dependent deacetylase activity that is specific for HISTONES and a mono-ADP-ribosyltransferase activity.

A sirtuin family member found primarily in MITOCHONDRIA. It is a multifunctional enzyme that contains a NAD-dependent deacetylase activity that is specific for HISTONES and a mono-ADP-ribosyltransferase activity.

The biochemical and electrophysiological interactions between the NERVOUS SYSTEM and IMMUNE SYSTEM that result in regulation of the immune system by the nervous system.

Quick Search

DeepDyve research library

Relevant Topics

Autoimmune Disorders
Autoimmune disorders are conditions that occurs when the immune system mistakenly attacks and destroys healthy body tissue. There are more than 80 different types of autoimmune disorders. Normally the immune system's white blood cells help protect ...

An antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Examples of antigens include microorganisms (such as bacteria, fungi, parasites, and viruses) and chemicals. Antibodies may be produc...

Searches Linking to this Article