Infrared attenuated total reflection (IR-ATR) spectroscopy for detecting drugs in human saliva.

06:00 EST 25th November 2011 | BioPortfolio

Summary of "Infrared attenuated total reflection (IR-ATR) spectroscopy for detecting drugs in human saliva."

The consumption of drugs is of great concern worldwide. Various drug tests for humans have been developed but there is no compact and easy-to-use test device available yet for direct semi-quantitative drug testing in the field. We suggest using attenuated total reflection (ATR) infrared spectroscopy as a sensing method to analyze human saliva samples with respect to drugs. In this paper, we present ATR spectra in the infrared range between 2300 and 900 cm(-1) as a first step towards such a device. We emphasize the common drug cocaine and its metabolites and investigate the problems of spectral interferences of selected diluents, masking agents, common medication, and soft drinks. Furthermore, spectra of saliva samples are recorded and a time-dependent change of the spectral signatures after alcohol consumption is presented. To the best of our knowledge, it is the first time that not only spectra of the drug of interest (cocaine) dissolved in water and in saliva but also spectra of interfering compounds possibly present in the saliva sample of a tested subject are discussed. This paper presents the most appropriate spectral range for strong cocaine absorption (including its metabolites) and minimum interference by the investigated substances. This spectral window is found to be between 1800 and 1710 cm(-1) . In addition, we demonstrate the feasibility to identify cocaine in saliva at a concentration of 0.020 mg/ml with IR-ATR-spectroscopy without any separation or extraction procedures. For example, this technique could also be applied for drug detection in waste water. Copyright © 2011 John Wiley & Sons, Ltd.


ETH Zurich, Institute for Quantum Electronics, Zurich, Switzerland.

Journal Details

This article was published in the following journal.

Name: Drug testing and analysis
ISSN: 1942-7611


DeepDyve research library

PubMed Articles [30090 Associated PubMed Articles listed on BioPortfolio]

Critical Evaluation of NIR and ATR-IR Spectroscopic Quantifications of Rosmarinic Acid in Rosmarini folium Supported by Quantum Chemical Calculations.

The present study evaluates the analytical performance of near infrared as well as attenuated total reflection infrared spectroscopy for the determination of the rosmarinic acid content in Rosmarini f...

Complex refractive index spectra of whole blood and aqueous solutions of anticoagulants, analgesics and buffers in the mid-infrared.

Mid-infrared (MIR) spectroscopy is a powerful tool for characterising the vibrations of molecular bonds and is therefore ideal for label-free detection of chemical species. Recent research into thin-f...

Identification of trace additives in polymer materials by attenuated total reflection Fourier transform infrared mapping coupled with multivariate curve resolution.

Although multivariate curve resolution (MCR) has been applied to the analysis of Fourier transform infrared (FTIR) imaging, it is still problematic to determine the number of components. The reported ...

Depth-selective photothermal IR spectroscopy of skin: potential application for non-invasive glucose measurement.

An infrared spectroscopic technique is described that employs a mid-IR broadband (980-1245 cm(-1)) tunable quantum cascade laser (QCL) to produce a pump beam, and a detection method based on photother...

Supramolecular Photoactivatable Anticancer Hydrogels.

A photoactivatable dopamine-conjugated platinum(IV) anticancer complex (Pt-DA) has been incorporated into G-quadruplex G4K(+) borate hydrogels by using borate ester linkages (Pt-G4K(+)B hydrogel). The...

Clinical Trials [6102 Associated Clinical Trials listed on BioPortfolio]

The Development of an In-vitro System to Identify Gynecologic Cancer Cells During Surgical Procedures

The purpose of this study is to examine the efficacy of mid-infrared spectroscopy together with Attenuated Total Reflection (ATR), for the detection of gynecological malignancies in real t...

Using Infrared Spectroscopy for Diagnosis Severity of Nonalcoholic Fatty Liver Disease

The main objective of this study is to evaluate the ability of infrared spectroscopy to discriminate simple hepatic steatosis from NASH

Study of Near Infrared Spectroscopy (NIRS) and Intravascular Ultrasound (IVUS) Combination Coronary Catheter

This study is designed to evaluate the technical performance and clinical handling of a coronary catheter that includes two imaging techniques. The catheter being evaluated performs near ...

NIRS Measurement After SCP Block

Peripheral regional anesthesia induces a sympathectomy-like effect with neurovascular changes causing increased arterial blood flow and venodilatation . Near-infrared spectroscopy (NIRS) ...

Assessment of Near Infrared Spectroscopy as a Diagnostic Tool in Acute Compartment Syndrome

The purpose of this study is to define the reliability and accuracy of Near Infrared Spectroscopy (NIRS) in the detection of intra-compartmental tissue perfusion in injured and noninjured ...

Medical and Biotech [MESH] Definitions

A noninvasive technique that uses the differential absorption properties of hemoglobin and myoglobin to evaluate tissue oxygenation and indirectly can measure regional hemodynamics and blood flow. Near-infrared light (NIR) can propagate through tissues and at particular wavelengths is differentially absorbed by oxygenated vs. deoxygenated forms of hemoglobin and myoglobin. Illumination of intact tissue with NIR allows qualitative assessment of changes in the tissue concentration of these molecules. The analysis is also used to determine body composition.

A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.

Measurement of the regional temperature of the body or an organ by infrared sensing devices, based on self-emanating infrared radiation.

Spectroscopy technique which measures changes in organic compounds by tracking the spectral energy of absorption of HYDROGEN atoms.

That portion of the electromagnetic spectrum usually sensed as heat. Infrared wavelengths are longer than those of visible light, extending into the microwave frequencies. They are used therapeutically as heat, and also to warm food in restaurants.

Quick Search

DeepDyve research library

Relevant Topics

Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

Searches Linking to this Article