Validation of an immunohistochemical signature predictive of 8-year outcome for patients with breast carcinoma.
Summary of "Validation of an immunohistochemical signature predictive of 8-year outcome for patients with breast carcinoma."
We recently reported that standardized quantitative immunohistochemical (IHC) assays allowed prediction of an adverse outcome among 572 node negative (N-) patients with breast carcinoma (BrCa). To further validate our prior findings, we repeated the IHC stains including a second series of BrCa diagnosed at Yale University. Tissue micro-arrays TMA of two cohorts of patients with BrCa (418 Marseille University and 303 Yale University) were respectively investigated for IHC expression of 15 markers, (HIF-1α, PI3K, pAKT, pmTOR, moesin, P21, 4(E) BP-1, P27, Ker5-6, pMAPKAPK-2, SHARP2, Claudin-1, ALDH, AF6, CD24). Quantitative measurements of immunoprecipitates densitometry assessed with an image analyzer were correlated with 8 year patients outcome and compared in the two cohorts. © 2011 Wiley-Liss, Inc.
Affiliation
INSERM U624 and CHU Nord, Marseille, France. colette.charpin@ap-hm.fr.
Journal Details
This article was published in the following journal.
Name: International journal of cancer. Journal international du cancer
ISSN: 1097-0215
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22120430
- DOI: http://dx.doi.org/10.1002/ijc.27371
Medical and Biotech [MESH] Definitions
Predictive Value Of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
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