Power Doppler breast ultrasound: association of vascularization and ER/c-erbB-2 co-expression in invasive breast carcinoma.
Summary of "Power Doppler breast ultrasound: association of vascularization and ER/c-erbB-2 co-expression in invasive breast carcinoma."
Angiogenesis is a fundamental component of oncogenesis. In this study we provided morphologic evidence of vascularization by using power Doppler ultrasound to correlate the clinicopathologic features of tumorigenesis, ER/c-erbB-2 expression, and tumor grade in invasive breast carcinoma.
Three indices (VI, vascularization index; FI, flow index; VFI, vascularization flow index) were used to analyze 3D power Doppler ultrasound images from 168 patients with malignant breast carcinoma and to correlate their clinicopathologic features.
VI (the mean tumor vascularity) was correlated with ER negativity (p < 0.0029) and VFI (the overall perfusion) was correlated with ER positivity (p < 0.0029). HER2 positivity was statistically significantly correlated with tumor vasculature (VI, VFI) and tumor size/volume. FI (the mean blood flow volume) was significantly correlated with tumor size/volume, but VI was not. The univariate or multivariate logistic regression analysis also showed the reverse correlations between ER expression and tumor vascularity, and positive correlations between HER2 expression and tumor vascularity as well as tumor volume.
This morphologic evidence of vascularization is correlated with tumor angiogenesis and ER/c-erbB-2 co-expression, which could clarify the biology of breast cancer.
Comprehensive Breast Cancer Center, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua, 500, Taiwan.
This article was published in the following journal.
Name: Breast cancer (Tokyo, Japan)
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22124997
- DOI: http://dx.doi.org/10.1007/s12282-011-0317-y
Medical and Biotech [MESH] Definitions
Retrovirus-associated DNA sequences (erbB) originally isolated from, or related to, the avian erythroblastosis virus (AEV). These genes code for the epidermal growth factor receptor (EGFR) family of receptors which is important in the control of normal cell proliferation and in the pathogenesis of human cancer. The genes include erbB-1 (GENES, ERBB-1), erbB-2 (GENES, ERBB-2), and erbB-3, all of which show abnormalities of expression in various human neoplasms.
Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)
Ultrasonography, Doppler, Duplex
Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.
Ultrasonography, Doppler, Pulsed
Ultrasonography applying the Doppler effect, with velocity detection combined with range discrimination. Short bursts of ultrasound are transmitted at regular intervals and the echoes are demodulated as they return.
Echocardiography, Doppler, Pulsed
Echocardiography applying the Doppler effect, with velocity detection combined with range discrimination. Short bursts of ultrasound are transmitted at regular intervals and the echoes are demodulated as they return.
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