Gender differences in cholesterol-lowering medication prescribing in peripheral artery disease.
Summary of "Gender differences in cholesterol-lowering medication prescribing in peripheral artery disease."
Among 320 patients with lower extremity peripheral artery disease (PAD) and low-density lipoprotein-cholesterol (LDL-C) levels > 70 mg/dl, we determined whether male sex, higher education, and greater self-efficacy for willingness to request therapy from one's physician were associated with increases in LDL-C-lowering medication and achievement of an LDL-C level < 70 mg/dl at 1-year follow-up. Participants were enrolled in a randomized controlled clinical trial to determine whether a telephone counseling intervention can help PAD patients achieve an LDL-C level < 70 mg/dl, compared to usual care and attention control conditions, respectively. Adjusting for age, race, comorbidities, PAD severity, and other covariates, male sex (odds ratio = 3.33, 95% confidence interval = 1.64 to 6.77, p = 0.001) was associated with a higher likelihood of adding cholesterol-lowering medication during follow-up, but was not associated with achieving an LDL-C < 70 mg/dl (odds ratio = 1.09, 95% confidence interval = 0.55 to 2.18). No associations of education level or self-efficacy with study outcomes were identified. In conclusion, male PAD patients with baseline LDL-C levels ≥ 70 mg/dl were more likely to intensify LDL-C-lowering medication during 1-year follow-up than female PAD patients. Despite greater increases in LDL-C-lowering medication among female PAD patients, there was no difference in the degree of LDL-C lowering during the study between men and women with PAD. Clinical Trial Registration -
URL:
http://www.clinicaltrials.gov/ct2/show/NCT00217919.
Affiliation
1 Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Journal Details
This article was published in the following journal.
Name: Vascular medicine (London, England)
ISSN: 1477-0377
Pages: 428-35
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22128042
- DOI: http://dx.doi.org/10.1177/1358863X11425879
Medical and Biotech [MESH] Definitions
Medication Errors
Errors in prescribing, dispensing, or administering medication with the result that the patient fails to receive the correct drug or the indicated proper drug dosage.
Functional Food
Components of the usual diet that may provide health benefits beyond basic nutrients. Examples of functional foods include soy, nuts, chocolate, and cranberries (From NCCAM Backgrounder, March 2004, p3). Soy, for example, provides not only protein but also PHYTOESTROGENS (isoflavones), which help reduce total blood cholesterol by lowering LDL CHOLESTEROL.
Inappropriate Prescribing
The practice of prescribing medications in a manner that poses more risk than benefit, particularly where safer alternatives exist.
Lecithin Acyltransferase Deficiency
An autosomal recessively inherited disorder caused by mutation of LECITHIN CHOLESTEROL ACYLTRANSFERASE that facilitates the esterification of lipoprotein cholesterol and subsequent removal from peripheral tissues to the liver. This defect results in low HDL-cholesterol level in blood and accumulation of free cholesterol in tissue leading to a triad of CORNEAL OPACITY, hemolytic anemia (ANEMIA, HEMOLYTIC), and PROTEINURIA.
Catheterization, Peripheral
Insertion of a catheter into a peripheral artery, vein, or airway for diagnostic or therapeutic purposes.
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