Advertisement
Advertise here Publish your press releases here Sponsor BioPortfolio
Follow us on Twitter Sign up for daily news and research emails Contributors wanted

Plasma homocysteine, serum folic acid, serum vitamin B12, serum vitamin B6, MTHFR and risk of pseudoexfoliation glaucoma: a meta-analysis.

05:46 EDT 21st April 2014 | BioPortfolio

Summary of "Plasma homocysteine, serum folic acid, serum vitamin B12, serum vitamin B6, MTHFR and risk of pseudoexfoliation glaucoma: a meta-analysis."


BACKGROUND:
The aim of this meta-analysis is to explore the relationship between plasma total homocysteine (tHcy) levels, serum folic acid, vitamin B12 and vitamin B6 levels, methylenetetrahydrofolate reductase (MTHFR) C677T genotype and risk of pseudoexfoliation glaucoma (PEXG).
METHODS:
A systematic search of EMBASE and PubMed of relevant articles was carried out for all published articles. Main outcome measures included the calculation of plasma tHcy levels, serum folic acid, vitamin B12, and vitamin B6 levels mean difference and odds ratios (OR) of MTHFR C677T genotype between cases and controls.
RESULTS:
There were 14 studies for tHcy (485 cases and 456 controls), five studies for folic acid (188 cases and 189 controls), six studies for vitamin B12 (199 cases and 225 controls), three studies for vitamin B6 (128 cases and 130 controls) and eight studies for MTHFR (479 cases and 661 controls). Overall, the mean plasma tHcy levels in cases was 3.38 umol/l (95% confidence intervals (CI): 2.35-4.42) higher than in controls. Serum folic acids, but not vitamin B12 and vitamin B6 levels, was significantly lower in cases than in controls; the weighted mean differences with 95% CI were -1.50 umol/l (-2.53, -0.46), -36.29 umol/l (-81.27, 8.68) and -0.60 umol/l (-2.55, 1.35) respectively. There was no evidence of association between the MTHFR C677T genotype and PEXG (OR = 1.28, 95%
CI:
0.85, 1.93).
CONCLUSIONS:
PEXG is associated with elevated plasma tHcy and low serum folic acid levels, but not serum vitamin B12, vitamin B6 levels, and MTHFR C677T genotype.

Affiliation

Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, No.6, Taoyuan Road, Nanning, Guangxi, 530021, People's Republic of China.

Journal Details

This article was published in the following journal.

Name: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Opht
ISSN: 1435-702X
Pages:

Links

PubMed Articles [11512 Associated PubMed Articles listed on BioPortfolio]

Effects of folic acid plus levothyroxine on serum homocysteine level in hypothyroidism.

Background: Rise in serum homocysteine level may be associated with higher prevalence of cardiovascular diseases in hypothyroidism. Levothyroxine can partly diminish serum homocysteine level. Folic ac...

Serum and red blood cell folate testing for folate deficiency: new features?

Folate deficiency is assessed by serum and red blood cell folate measurements. Nevertheless, no consensus for the lower limit of serum folate reference values exists. We investigated the appropriate u...

The effect of multiple single nucleotide polymorphisms in the folic Acid pathway genes on homocysteine metabolism.

Objective. To investigate the joint effects of the single nucleotide polymorphisms (SNPs) of genes in the folic acid pathway on homocysteine (Hcy) metabolism. Methods. Four hundred women with normal p...

Homocysteine, an additional factor, is linked to osteoporosis in postmenopausal women with type 2 diabetes.

We explored the relationship between plasma total homocysteine concentration and osteoporosis in postmenopausal patients with type 2 diabetes. Postmenopausal patients with type 2 diabetes (n = 258)...

Dietary glycemic index, but not glycemic load, is positively associated with serum homocysteine concentration in free-living young Japanese women.

It has been suggested that diets which enhance diurnal insulin secretion, such as a high glycemic index (GI) and glycemic load (GL) diet, can be expected to increase homocysteine levels. We investigat...

Clinical Trials [3514 Associated Clinical Trials listed on BioPortfolio]

Vitamin B12 and Folic Acid Supplementation for Preventing Fractures in Elderly People

It is hypothesized that vitamin B12 and folic acid supplementation reduces the number of incident fractures. The proposed study, a randomized placebo-controlled intervention trial, compare...

The Study of Relationship of Plasma Concentrations of Folic Acid, Vitamin B and Homocysteine With Carotid Atherosclerosis and Endothelium-Dependent Vasodilatation of Geriatric and Young Patients in the Ambulatory Care Department of NTUH

Elevation of plasma homocysteine has been recognized as one of the risk factors of atherosclerotic disease. The objectives of this study are: (1) to investigate the level of plasma homocys...

Evaluating the Effects of Folic Acid Supplementation in Older Adults: The Folic Acid Supplementation Trial (The FAST Study)

High levels of homocysteine, which is an amino acid in the blood, have been linked to an increased risk of heart disease. This study will examine the effect that differing levels of folic...

Metformin and Folate in Pregnant Polycystic Ovary Syndrome(PCOS) Women

A more recent prospective nonrandomized placebo-controlled double-blind clinical study demonstrated that metformin exerts a slight but significant deleterious effect on serum homocysteine...

Blood Folate and Homocysteine Levels Following Administration of Folic Acid According to Different Daily Dosing Schedules:a Simulation of Food Fortification

The aim of this study is to examine whether the same total daily dosage of folic acid, when taken as a single daily dose or as multiple divided doses throughout the day, results in differe...

Medical and Biotech [MESH] Definitions

Immune complex disease caused by the administration of foreign serum or serum proteins and characterized by fever, lymphadenopathy, arthralgia, and urticaria. When they are complexed to protein carriers, some drugs can also cause serum sickness when they act as haptens inducing antibody responses.

All blood proteins except albumin ( = SERUM ALBUMIN, which is not a globulin) and FIBRINOGEN (which is not in the serum). The serum globulins are subdivided into ALPHA-GLOBULINS; BETA-GLOBULINS; and GAMMA-GLOBULINS on the basis of their electrophoretic mobilities. (From Dorland, 28th ed)

The first alpha-globulins to appear in mammalian sera during development of the embryo and the dominant serum proteins in early embryonic life. They reappear in the adult serum during certain pathologic states, primarily hepatocellular carcinoma. They may also be elevated in the amniotic fluid and maternal serum during pregnancy in ANENCEPHALY.

An inherited autosomal dominant trait characterized by abnormally elevated levels of total serum THYROXINE; (T4) in euthyroid patients with abnormal SERUM ALBUMIN that binds T4 with enhanced affinity. The serum levels of free T4, free T3, and TSH are normal. It is one of several T4 abnormalities produced by non-thyroid disorder. This condition is due to mutations of the ALB gene on CHROMOSOME 4.

Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.

Search BioPortfolio: