History of Major Depressive Disorder Prospectively Predicts Worse Quality of Life in Women with Breast Cancer.
Summary of "History of Major Depressive Disorder Prospectively Predicts Worse Quality of Life in Women with Breast Cancer."
BACKGROUND:
Data are scarce about whether past history of major depressive disorder in the absence of current depression places breast cancer patients at risk for worse quality of life.
PURPOSE:
The current study prospectively examined quality of life during chemotherapy in breast cancer patients with a history of resolved major depressive disorder (n = 29) and no history of depression (n = 144).
METHODS:
Women with Stages 0-II breast cancer were assessed prior to and at the completion of chemotherapy. Major depressive disorder was assessed via structured interview and quality of life with the SF-36.
RESULTS:
Patients with past major depressive disorder displayed greater declines in physical functioning relative to patients with no history of depression (p ≤ 0.01).
CONCLUSIONS:
Findings suggest that breast cancer patients with a history of resolved major depressive disorder are at increased risk for declines in physical functioning during chemotherapy relative to patients with no history of depression.
Affiliation
Moffitt Cancer Center, 12902 Magnolia Drive, MRC-PSY, Tampa, 33612, FL, USA, heather.jim@moffitt.org.
Journal Details
This article was published in the following journal.
Name: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
ISSN: 1532-4796
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22167580
- DOI: http://dx.doi.org/10.1007/s12160-011-9333-6
Medical and Biotech [MESH] Definitions
Bipolar Disorder
A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
Trazodone
A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
Depressive Disorder, Major
Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.
Depressive Disorder
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
Antisocial Personality Disorder
A personality disorder whose essential feature is a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood. The individual must be at least age 18 and must have a history of some symptoms of CONDUCT DISORDER before age 15. (From DSM-IV, 1994)
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