Oral squamous cell carcinoma in human immunodeficiency virus positive patients: clinicopathological audit.
Summary of "Oral squamous cell carcinoma in human immunodeficiency virus positive patients: clinicopathological audit."
Background:Most human immunodeficiency virus positive patients now have a longer life expectancy, with the advent of highly active antiretroviral therapy. However, they are now at increased risk of developing a malignancy during their lives.Aim:To investigate the age at which oral squamous cell carcinoma presents in patients infected with human immunodeficiency virus.Study design:Prospective, clinicohistopathological audit of patients infected with human immunodeficiency virus.Results:Of 200 human immunodeficiency virus positive patients, 16 (8 per cent) presented with oral squamous cell carcinoma (nine women and seven men; age range 18-43 years, mean age 31.7 years). The majority of patients (62.5 per cent) had stage III and IV disease (tumour-node-metastasis staging). There was a predilection for poorly differentiated oral squamous cell carcinoma (using Broder's histopathological classification).Conclusion:Oral squamous cell carcinoma associated with human immunodeficiency virus infection appears to present at a relatively young age.
Affiliation
Department of Human Anatomy, University of Nairobi, Kenya.
Journal Details
This article was published in the following journal.
Name: The Journal of laryngology and otology
ISSN: 1748-5460
Pages: 1-3
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22166489
- DOI: http://dx.doi.org/10.1017/S0022215111002647
Medical and Biotech [MESH] Definitions
Carcinoma, Squamous Cell
A carcinoma derived from stratified squamous epithelium. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Carcinoma, Non-small-cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Rev Gene Products, Human Immunodeficiency Virus
Proteins encoded by the REV GENES of the HUMAN IMMUNODEFICIENCY VIRUS.
Vif Gene Products, Human Immunodeficiency Virus
Proteins encoded by the VIF GENES of the HUMAN IMMUNODEFICIENCY VIRUS.
Nef Gene Products, Human Immunodeficiency Virus
Proteins encoded by the NEF GENES of the HUMAN IMMUNODEFICIENCY VIRUS.
PubMed Articles
ABSTRACT: Human papillomavirus (HPV) infection of the mouth and oropharynx can be acquired by a variety of sexual and social forms of transmission. HPV-16 genotype is present in many oral and orophary...
The mammalian target of rapamycin (mTOR) is engaged in the molecular pathogenesis of oral squamous cell carcinoma which frequently invades the maxilla or the mandible. However, the effects of an mTOR...
The present study focuses on the correlation between the expression pattern of β-catenin (component of Wnt signaling), ΔNp63 (proliferation marker), and Notch 1 (transmembrane receptor) in oral squa...
Spindle cell carcinoma is an uncommon variant of squamous cell carcinoma characterized by spindled or pleomorphic cells which appear to be a true sarcoma but are actually epithelial. Some head and nec...
Surgical treatment is recommended for advanced oral squamous cell carcinoma.
Oral squamous cell carcinoma is one of the most frequent types of head and neck cancers in Japan. Although recent reports have shown positive results of non-surgical treatment for advanced head and ne...
Clinical Trials
Human Papillomavirus on Oral Tissue, Saliva and Serum
Human papillomavirus (HPV) is one of the most prevalent infections in the world with several millions of new cases diagnosed yearly. Oral HPV infection may be associated with different dis...
Combination Chemotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck
The purpose of this study is to further test a combination chemotherapy regimen for the treatment of squamous cell carcinoma of the head and neck and to see if the addition of supportive m...
MAGE-A3/HPV 16 Vaccine for Squamous Cell Carcinoma of the Head and Neck
Squamous Cell Carcinoma of the Head and Neck (SCCHN) is a devastating illness, the treatment of which is associated with significant morbidity. This type of cancer affects 43,000 individua...
NATURAL HISTORY-Hepatitis C Virus/ Human Immunodeficiency Virus Coinfection
The purpose of this study was to describe the time course and extent of hemoglobin (Hb) changes and the erythropoietic response to PEG-IFN/RBV (Pegylated Interferon and Ribavirin)-induced...
Four Doses of MAGE Vaccine for Patients With Squamous Cell Carcinoma of the Head and Neck
Squamous Cell Carcinoma of the Head and Neck (SCCHN) effects 43,000 individuals in the United States annually with an estimated overall survival of 50%. For some patients who develop loca...
