Age-Dependent Changes in the Membrane Surface Area: Sickle Red Blood Cell Volume May Account for Differential Clinical Effects of Coinherited α Thalassemia on Sickle Cell Anemia.
Summary of "Age-Dependent Changes in the Membrane Surface Area: Sickle Red Blood Cell Volume May Account for Differential Clinical Effects of Coinherited α Thalassemia on Sickle Cell Anemia."
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Emeritus Professor of Medicine, the University of California - San Francisco Chief Executive Officer, Vanguard Therapeutics, Inc. 108 Eagle Trace Drive Half Moon Bay, CA 94019.
This article was published in the following journal.
Name: European journal of haematology
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22168478
- DOI: http://dx.doi.org/10.1111/j.1600-0609.2011.01743.x
Medical and Biotech [MESH] Definitions
An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.
Hemoglobin Sc Disease
One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin C. It is similar to, but less severe than sickle cell anemia.
Exchange Transfusion, Whole Blood
Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria.
Cell Surface Extensions
Specialized structures of the cell that extend the cell membrane and project out from the cell surface.
The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA.
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