Pioglitazone: beyond glucose control.
Summary of "Pioglitazone: beyond glucose control."
Pioglitazone is an oral antidiabetic agent that decreases insulin resistance in adipose tissue, liver and muscles. This action is mediated by its link to a nuclear receptor called peroxisome proliferator-activated receptor-gamma. By improving insulin sensitivity, hepatic glucose production decreases and glucose uptake increases in the peripheral tissues. Beyond these effects on glucose metabolism, pioglitazone has positive effects on lipid metabolism, blood pressure, endothelial function, adiponectin and C-reactive protein levels. These make pioglitazone treatment effective beyond glucose control. In this article, current evidence concerning pioglitazone in the treatment of Type 2 diabetes will be reviewed.
Affiliation
Department of Endocrinology & Diabetes and Metabolism, Dr Negrin Hospital, Las Palmas University, Spain. ppablos@dcmq.ulpgc.es.
Journal Details
This article was published in the following journal.
Name: Expert review of cardiovascular therapy
ISSN: 1744-8344
Pages: 1057-67
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20670183
- DOI: http://dx.doi.org/10.1586/erc.10.98
Medical and Biotech [MESH] Definitions
Glucose Clamp Technique
Maintenance of a constant blood glucose level by perfusion or infusion with glucose or insulin. It is used for the study of metabolic rates (e.g., in glucose, lipid, amino acid metabolism) at constant glucose concentration.
Glucose Transporter Type 2
A glucose transport facilitator that is expressed primarily in PANCREATIC BETA CELLS; LIVER; and KIDNEYS. It may function as a GLUCOSE sensor to regulate INSULIN release and glucose HOMEOSTASIS.
Glucose-6-phosphatase
An enzyme that catalyzes the conversion of D-glucose 6-phosphate and water to D-glucose and orthophosphate. EC 3.1.3.9.
Glucose Tolerance Test
A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).
Glucose Transporter Type 1
A ubiquitously expressed glucose transporter that is important for constitutive, basal GLUCOSE transport. It is predominately expressed in ENDOTHELIAL CELLS and ERYTHROCYTES at the BLOOD-BRAIN BARRIER and is responsible for GLUCOSE entry into the BRAIN.
PubMed Articles
Pioglitazone for Diabetes Prevention.
To the Editor: DeFronzo and colleagues (March 24 issue)(1) reported that pioglitazone reduced the conversion from a condition of impaired glucose tolerance to type 2 diabetes. However, the results sho...
Pioglitazone for Diabetes Prevention.
To the Editor: DeFronzo and colleagues (March 24 issue)(1) reported that pioglitazone reduced the conversion from a condition of impaired glucose tolerance to type 2 diabetes. However, the results sho...
Pioglitazone for Diabetes Prevention.
To the Editor: DeFronzo and colleagues (March 24 issue)(1) reported that pioglitazone reduced the conversion from a condition of impaired glucose tolerance to type 2 diabetes. However, the results sho...
Pioglitazone is an anti-diabetic agent that preserves pancreatic beta cell mass and improves their function. Advanced Glycation End-Products (AGEs) are implicated in diabetic complications. We previou...
The peroxisome proliferator-activated receptor γ (PPARγ) has important effects on insulin sensitivity, obesity and diabetes. Pioglitazone improves insulin sensitivity by activating PPARγ. In view o...
Clinical Trials
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