CYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: a systematic review and meta-analysis.
Summary of "CYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: a systematic review and meta-analysis."
The US Food and Drug Administration recently recommended that CYP2C19 genotyping be considered prior to prescribing clopidogrel, but the American Heart Association and American College of Cardiologists have argued evidence is insufficient to support CYP2C19 genotype testing.
Affiliation
Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, 1-19 Torrington Pl, London, WC1E 6BT, United Kingdom. mvholmes@gmail.com
Journal Details
This article was published in the following journal.
Name: JAMA : the journal of the American Medical Association
ISSN: 1538-3598
Pages: 2704-14
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22203539
- DOI: http://dx.doi.org/10.1001/jama.2011.1880
Medical and Biotech [MESH] Definitions
Platelet Activation
A series of progressive, overlapping events, triggered by exposure of the PLATELETS to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
Cardiovascular Physiological Processes
Biological actions and events that support the functions of the CARDIOVASCULAR SYSTEM.
Cardiovascular Deconditioning
A change in cardiovascular function resulting in a reduction in BLOOD VOLUME, and reflex DIURESIS. It occurs frequently after actual or simulated WEIGHTLESSNESS.
Blood Platelet Disorders
Disorders caused by abnormalities in platelet count or function.
Clot Retraction
Retraction of a clot resulting from contraction of PLATELET pseudopods attached to FIBRIN strands. The retraction is dependent on the contractile protein thrombosthenin. Clot retraction is used as a measure of platelet function.
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