Rapid spontaneous regression of acute-onset vulvar intraepithelial neoplasia 3 in young women: a case series.
Summary of "Rapid spontaneous regression of acute-onset vulvar intraepithelial neoplasia 3 in young women: a case series."
Vulvar intraepithelial neoplasia 3 (VIN 3)/vulvar carcinoma in situ is currently treated by surgical excision, laser ablation, or topically with 5-fluorouracil or imiquimod. The rate of progression of untreated VIN 3/vulvar carcinoma in situ to invasive cancer is significant, although difficult to assess, because most patients undergo treatment. The peak incidence of invasive carcinoma of the vulva occurs in the sixth decade, which may indicate that human papillomavirus (HPV)-related preinvasive disease in the younger population has a lower progression rate. However, the risk of invasive disease cannot be disregarded.
Affiliation
1Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, Saint Barnabas Medical Center, Livingston; and 2Gynecologic Cancer & Pelvic Surgery LLC, West Orange, NJ.
Journal Details
This article was published in the following journal.
Name: Journal of lower genital tract disease
ISSN: 1526-0976
Pages: 56-8
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22207153
- DOI: http://dx.doi.org/10.1097/LGT.0b013e31822d93ee
Medical and Biotech [MESH] Definitions
Abdomen, Acute
A clinical syndrome with acute abdominal pain that is severe, localized, and rapid onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases.
Prostatic Intraepithelial Neoplasia
A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.
Embolism, Cholesterol
Blocking of a blood vessel by CHOLESTEROL-rich atheromatous deposits, generally occurring in the flow from a large artery to small arterial branches. It is also called arterial-arterial embolization or atheroembolism which may be spontaneous or iatrogenic. Patients with spontaneous atheroembolism often have painful, cyanotic digits of acute onset.
Neoplasm Regression, Spontaneous
Disappearance of a neoplasm or neoplastic state without the intervention of therapy.
Encephalomyelitis, Acute Disseminated
An acute or subacute inflammatory process of the CENTRAL NERVOUS SYSTEM characterized histologically by multiple foci of perivascular demyelination. Symptom onset usually occurs several days after an acute viral infection or immunization, but it may coincide with the onset of infection or rarely no antecedent event can be identified. Clinical manifestations include CONFUSION, somnolence, FEVER, nuchal rigidity, and involuntary movements. The illness may progress to COMA and eventually be fatal. (Adams et al., Principles of Neurology, 6th ed, p921)
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