Rapid spontaneous regression of acute-onset vulvar intraepithelial neoplasia 3 in young women: a case series.
Summary of "Rapid spontaneous regression of acute-onset vulvar intraepithelial neoplasia 3 in young women: a case series."
Vulvar intraepithelial neoplasia 3 (VIN 3)/vulvar carcinoma in situ is currently treated by surgical excision, laser ablation, or topically with 5-fluorouracil or imiquimod. The rate of progression of untreated VIN 3/vulvar carcinoma in situ to invasive cancer is significant, although difficult to assess, because most patients undergo treatment. The peak incidence of invasive carcinoma of the vulva occurs in the sixth decade, which may indicate that human papillomavirus (HPV)-related preinvasive disease in the younger population has a lower progression rate. However, the risk of invasive disease cannot be disregarded.
1Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, Saint Barnabas Medical Center, Livingston; and 2Gynecologic Cancer & Pelvic Surgery LLC, West Orange, NJ.
This article was published in the following journal.
Name: Journal of lower genital tract disease
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22207153
- DOI: http://dx.doi.org/10.1097/LGT.0b013e31822d93ee
Medical and Biotech [MESH] Definitions
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Prostatic Intraepithelial Neoplasia
A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.
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Neoplasm Regression, Spontaneous
Disappearance of a neoplasm or neoplastic state without the intervention of therapy.
Encephalomyelitis, Acute Disseminated
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