Simultaneous confidence bands for comparisons to placebo, with application to detecting the minimum effective dose.
Summary of "Simultaneous confidence bands for comparisons to placebo, with application to detecting the minimum effective dose."
In this article we consider a max-min approach to construct two-sided and one-sided simultaneous confidence bands in a dose-response study for the contrast in mean responses of each ascending dose versus placebo. The method utilizes the assumption of monotone non-decreasing dose-response curve. Also discussed is a step-down testing procedure that utilizes the lower bands to estimate the minimum effective dose (MED). The performance of our proposed step-down procedure is assessed by simulations and is shown to be superior to competitors when the MED is the lowest dose in a dose-response study.
a Department of Statistics , University of Nebraska-Lincoln , Lincoln , Nebraska , USA.
This article was published in the following journal.
Name: Journal of biopharmaceutical statistics
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22204529
- DOI: http://dx.doi.org/10.1080/10543406.2010.504905
Medical and Biotech [MESH] Definitions
Multiple protein bands serving as markers of specific ANTIBODIES and detected by ELECTROPHORESIS of CEREBROSPINAL FLUID or serum. The bands are most often seen during inflammatory or immune processes and are found in most patients with MULTIPLE SCLEROSIS.
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
Confidence in or reliance on a person or thing.
Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.
An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.
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