Simultaneous confidence bands for comparisons to placebo, with application to detecting the minimum effective dose.
Summary of "Simultaneous confidence bands for comparisons to placebo, with application to detecting the minimum effective dose."
In this article we consider a max-min approach to construct two-sided and one-sided simultaneous confidence bands in a dose-response study for the contrast in mean responses of each ascending dose versus placebo. The method utilizes the assumption of monotone non-decreasing dose-response curve. Also discussed is a step-down testing procedure that utilizes the lower bands to estimate the minimum effective dose (MED). The performance of our proposed step-down procedure is assessed by simulations and is shown to be superior to competitors when the MED is the lowest dose in a dose-response study.
Affiliation
a Department of Statistics , University of Nebraska-Lincoln , Lincoln , Nebraska , USA.
Journal Details
This article was published in the following journal.
Name: Journal of biopharmaceutical statistics
ISSN: 1520-5711
Pages: 93-108
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22204529
- DOI: http://dx.doi.org/10.1080/10543406.2010.504905
Medical and Biotech [MESH] Definitions
Oligoclonal Bands
Multiple protein bands serving as markers of specific ANTIBODIES and detected by ELECTROPHORESIS of CEREBROSPINAL FLUID or serum. The bands are most often seen during inflammatory or immune processes and are found in most patients with MULTIPLE SCLEROSIS.
Heart-lung Transplantation
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
Trust
Confidence in or reliance on a person or thing.
Therapeutic Misconception
Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.
Placebo Effect
An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.
PubMed Articles
Simultaneous confidence intervals of risk differences in stratified paired designs.
In stratified matched-pair studies, risk difference between two proportions is one of the most frequently used indices in comparing efficiency between two treatments or diagnostic tests. This article...
Comparing quantile residual life functions by confidence bands.
In this article we present a nonparametric method for constructing confidence bands for the difference of two quantile residual life (qrl) functions. These bands provide evidence for two random variab...
Simultaneous confidence bounds for relative risks in multiple comparisons to control.
We discuss the construction of asymptotic simultaneous upper confidence limits that jointly bound relative risks formed by comparing several treatments to a control. Motivated by a vaccine study, we i...
The internet provides a pervasive milieu for healthcare delivery. The purpose of this study was to determine the effectiveness of a novel web-based cognitive behavioral therapy (CBT) course delivered...
Sertraline improves the somatic and psychological symptoms of the climacteric syndrome.
ABSTRACT Objective To evaluate the efficacy of sertraline versus placebo in the management of somatic and psychological complaints of the climacteric syndrome. Methods We conducted a randomized, doubl...
Clinical Trials
Does Acupressure Help Reduce Nausea and Vomiting in Palliative Care Patients? Formal Study
Pilot study completed - power calculation performed. Now formal double blind randomized study comparing active with placebo wristbands for nausea in palliative care patients to be carried...
Phase II Study Concomitant High-Dose Radio-Immuno- and Chemotherapy with simultaneous application of Zevalin and BEAM followed by autologous peripheral stem cell transplantation in relapse...
RATIONALE: Pressure or nerve stimulation applied to an acupuncture point on the inside of the wrist may help control nausea and vomiting during chemotherapy. PURPOSE: Randomized phase II...
Simultaneous Fluoroscopic and Manometric Measures of the Oropharyngeal Phase of Deglutition
To validate the pharyngeal constriction ration, a surrogate measure of pharyngeal strength on fluoroscopy by comparing it with simultaneous pharyngeal manometry.
Myopia Control With Simultaneous Vision Approach
The investigators hypothesize that the natural process of emmetropization in human is regulated by the equilibrium between the opposite hyperopic and myopic defocus. A sharp focus of retin...
