BVPaP-3, a T7-Like Lytic Phage of Pseudomonas aeruginosa: Its Isolation and Characterisation.
Summary of "BVPaP-3, a T7-Like Lytic Phage of Pseudomonas aeruginosa: Its Isolation and Characterisation."
The increasing emergence of antibiotic-resistant bacteria has produced a growing interest among scientists in bacteriophages as alternative antimicrobial agents. This article reports a lytic phage against an antibiotic-resistant strain of Pseudomonas aeruginosa. Phage BVPaP-3 is a member of the Podoviridae family and morphologically similar to the T7-like phage gh-1. The phage has a hexagonal head of 58-59 nm in diameter and a short tail of 10 × 8 nm. It is stable at a wide range of pH (6-10) and temperatures (4-40°C). Its optimal growth temperature is 37°C and the adsorption rate constant is 1.19 × 10(-9). Latent and eclipse periods are 20 and 15 min, respectively, and the burst size is 44 after 35 min at 37°C. The phage has a DNA size of 41.31 kb and a proteome of 11 proteins. The major protein is 33 kDa in size.
Department of Environmental Science, University of Pune, Pune, India.
This article was published in the following journal.
Name: Current microbiology
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22215482
- DOI: http://dx.doi.org/10.1007/s00284-011-0071-6
Medical and Biotech [MESH] Definitions
Viruses whose host is Pseudomonas. A frequently encountered Pseudomonas phage is BACTERIOPHAGE PHI 6.
A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
Bacteriophages whose genetic material is RNA, which is single-stranded in all except the Pseudomonas phage phi 6 (BACTERIOPHAGE PHI 6). All RNA phages infect their host bacteria via the host's surface pili. Some frequently encountered RNA phages are: BF23, F2, R17, fr, PhiCb5, PhiCb12r, PhiCb8r, PhiCb23r, 7s, PP7, Q beta phage, MS2 phage, and BACTERIOPHAGE PHI 6.
Antibiotic pigment produced by Pseudomonas aeruginosa.
A species of filamentous Pseudomonas phage in the genus INOVIRUS, family INOVIRIDAE.
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