EMT in carcinoma progression and dissemination: Facts, unanswered questions, and clinical considerations.
Summary of "EMT in carcinoma progression and dissemination: Facts, unanswered questions, and clinical considerations."
Over the past decade, much effort has been made to understand how cancers metastasize. In deciphering the metastatic process, a vast amount of work has focused on the role of the epithelial to mesenchymal transition (EMT), which, in experimental models, confers tumor cells with invasive and metastatic abilities, resistance to therapies, as well as cancer stem cell phenotype-properties that have a major impact on cancer prognosis. Searching "EMT and cancer" in PubMed retrieves thousands of original research articles, yet, we haven't answered the most basic question in the field: has EMT any relevance in human tumors?
Affiliation
OREGA BIOTECH, L'espace Européen, bat. G, 15 chemin du Saquin, Ecully, France, jeremy.bastid@orega-biotech.com.
Journal Details
This article was published in the following journal.
Name: Cancer metastasis reviews
ISSN: 1573-7233
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22215472
- DOI: http://dx.doi.org/10.1007/s10555-011-9344-6
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Information Science
The field of knowledge, theory, and technology dealing with the collection of facts and figures, and the processes and methods involved in their manipulation, storage, dissemination, publication, and retrieval. It includes the fields of COMMUNICATION; PUBLISHING; LIBRARY SCIENCE; and informatics.
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Carcinoma, Bronchogenic
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
Carcinoma 256, Walker
A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)
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